电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) 抗体

RIMS1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7043597
发货至: 中国
  • 抗原 See all Regulating Synaptic Membrane Exocytosis 1 (RIMS1) 抗体
    Regulating Synaptic Membrane Exocytosis 1 (RIMS1)
    抗原表位
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1039-1054, Intracellular
    适用
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 5
    • 1
    克隆类型
    • 6
    多克隆
    标记
    • 6
    非结合性
    应用范围
    • 6
    • 3
    • 3
    • 1
    Western Blotting (WB)
    原理
    A Rabbit Polyclonal Antibody to RIM1
    特异性
    Intracellular
    交叉反应
    小鼠, 大鼠
    预测反应
    human - 14,16 amino acid residues identical,Mouse - 15
    产品特性
    Anti-RIM1 Antibody is directed against an epitope of rat RIM1. Anti-RIM1 Antibody (ABIN7043597, ABIN7044528 and ABIN7044529) can be used in western blot analysis. It has been designed to recognize RIM1 from mouse, rat and human samples.
    纯化方法
    Affinity purified on immobilized antigen.
    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)RAKRGRSAESLHMTSE, corresponding to amino acid residues 1039-1054 of rat RIM1

    亚型
    IgG
    Top Product
    Discover our top product RIMS1 Primary Antibody
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    说明

    Negative Control: (ABIN7236714)

    Blocking Peptide: (ABIN7236714)

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4
    储存条件
    4 °C,-20 °C
    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原
    Regulating Synaptic Membrane Exocytosis 1 (RIMS1)
    别名
    RIMS1 (RIMS1 产品)
    背景
    Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1,RIM1 is a member of the RIM superfamily of proteins (Rim1-4). These genes express seven known RIM isoforms: RIM1α, 1β, RIM2α, 2β, 2γ, and RIM3γ and RIM4γ which serve as scaffolding proteins in presynaptic nerve terminals by interacting with several other protein components localized at the active zone, including Munc13, ELKS (or CAST), liprins and voltage-gated Ca2+ channels (VGCCs). RIM1 directly binds to the C-terminal regions of the α1 subunit of N- and P/Q-type calcium channels, and can also interact with the β auxiliary subunit of P/Q-type calcium channels1-3.RIM proteins were found to be required for normal Ca2+ triggering of exocytosis. This interaction with Ca2+ channel significantly slows channel inactivation resulting in increased Ca2+ influx during action potentials.Deficiency of RIM1 decreases presynaptic Ca2+ channel density. RIM proteins are involved in neurotransmitter release and contribute to long- and short-term synaptic plasticity.

    Alternative names: RIM1, Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1
    基因ID
    84556
    NCBI登录号
    NM_014989
    UniProt
    Q9JIR4
    途径
    Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
You are here:
客服