Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) 抗体
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- 抗原 See all Regulating Synaptic Membrane Exocytosis 1 (RIMS1) 抗体
- Regulating Synaptic Membrane Exocytosis 1 (RIMS1)
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抗原表位
- AA 1039-1054, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB)
- 原理
- A Rabbit Polyclonal Antibody to RIM1
- 特异性
- Intracellular
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- human - 14,16 amino acid residues identical,Mouse - 15
- 产品特性
- Anti-RIM1 Antibody is directed against an epitope of rat RIM1. Anti-RIM1 Antibody (ABIN7043597, ABIN7044528 and ABIN7044529) can be used in western blot analysis. It has been designed to recognize RIM1 from mouse, rat and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RAKRGRSAESLHMTSE, corresponding to amino acid residues 1039-1054 of rat RIM1
- 亚型
- IgG
- Top Product
- Discover our top product RIMS1 Primary Antibody
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anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 596-705) antibody
RIMS1 适用: 大鼠, 小鼠, 人, 小鸡, Frog, Hamster WB, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 207-366) antibodyRIMS1 适用: 大鼠, 小鼠 WB, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 955-1156) antibodyRIMS1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7236714)
Blocking Peptide: (ABIN7236714)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Regulating Synaptic Membrane Exocytosis 1 (RIMS1)
- 别名
- RIMS1 (RIMS1 产品)
- 背景
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Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1,RIM1 is a member of the RIM superfamily of proteins (Rim1-4). These genes express seven known RIM isoforms: RIM1α, 1β, RIM2α, 2β, 2γ, and RIM3γ and RIM4γ which serve as scaffolding proteins in presynaptic nerve terminals by interacting with several other protein components localized at the active zone, including Munc13, ELKS (or CAST), liprins and voltage-gated Ca2+ channels (VGCCs). RIM1 directly binds to the C-terminal regions of the α1 subunit of N- and P/Q-type calcium channels, and can also interact with the β auxiliary subunit of P/Q-type calcium channels1-3.RIM proteins were found to be required for normal Ca2+ triggering of exocytosis. This interaction with Ca2+ channel significantly slows channel inactivation resulting in increased Ca2+ influx during action potentials.Deficiency of RIM1 decreases presynaptic Ca2+ channel density. RIM proteins are involved in neurotransmitter release and contribute to long- and short-term synaptic plasticity.
Alternative names: RIM1, Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1 - 基因ID
- 84556
- NCBI登录号
- NM_014989
- UniProt
- Q9JIR4
- 途径
- Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
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