Prostaglandin D2 Receptor 2 (PTGDR2) (AA 270-283), (Extracellular) 抗体
Quick Overview for Prostaglandin D2 Receptor 2 (PTGDR2) (AA 270-283), (Extracellular) 抗体 (ABIN7043564)
抗原
See all Prostaglandin D2 Receptor 2 (PTGDR2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 270-283, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Prostanoid DP2 Receptor (CRTH2, GPR44)
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特异性
- 3rd extracellular loop
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Will not recognize DP2 receptor from human samples.
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预测反应
- Mouse - identical Will not recognize DP2 receptor from human samples
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产品特性
- Anti-CRTH2/GPR44 (extracellular) Antibody (ABIN7043564, ABIN7045118 and ABIN7045119) is a highly selective antibody directed against an epitope of the rat Prostanoid DP2 receptor. The antibody can be used in western blot, immunohistochemistry and live cell flow cytometry applications. The antibody recognizes an extracellular epitope and can potentially be used for detecting the protein in living cells. It has been designed to recognize DP2 receptor from mouse and rat samples. It is unlikely to recognize the receptor from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RAHSVTTLRQLASR, corresponding to amino acid residues 270-283 of rat PTGDR2
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亚型
- IgG
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anti-Prostaglandin D2 Receptor 2 (PTGDR2) (Extracellular Domain) antibody
PTGDR2 适用: 人, 猴 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin D2 Receptor 2 (PTGDR2) antibody (PE)PTGDR2 适用: 人 FACS 宿主: 大鼠 Monoclonal BM16 PE
anti-Prostaglandin D2 Receptor 2 (PTGDR2) antibody (APC)PTGDR2 适用: 人 FACS 宿主: 大鼠 Monoclonal BM16 APC
anti-Prostaglandin D2 Receptor 2 (PTGDR2) (N-Term) antibodyPTGDR2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin D2 Receptor 2 (PTGDR2) (Extracellular Domain) antibodyPTGDR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin D2 Receptor 2 (PTGDR2) antibodyPTGDR2 适用: 人 FACS 宿主: 大鼠 Monoclonal BM16 unconjugated
anti-Prostaglandin D2 Receptor 2 (PTGDR2) (AA 329-348) antibodyPTGDR2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Negative Control: (ABIN7236625)
Blocking Peptide: (ABIN7236625)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Prostaglandin D2 Receptor 2 (PTGDR2)
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别名
- PTGDR2
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背景
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Prostanoid DP2 receptor, Prostaglandin D2 receptor 2, PTGDR2, CD294,Prostanoids are potent oxygenated lipid molecules that contribute to a wide variety of physiological responses and pathological processes. There are currently five primary bioactive types of prostanoids: PGD2, PGE2, PGF2R, PGI2, and thromboxane A2 (TXA2).All prostanoid receptors belong to the G-protein coupled receptor superfamily. Unlike other receptors of this family the Prostaglandin D2 receptor (also known as CRTH2, GPR44) is structurally distinct and belongs to the family of leukocyte chemoattractant receptors.The DP2 receptor is expressed in Th2 cells, basophils, and eosinophils, and it mediates the chemotaxis of these cells in response to PGD2. The ability of PGD2 to promote eosinophil accumulation in the airways is mimicked by selective DP2 agonists but not DP1 agonists.Much effort has been directed toward developing DP2 agonists and antagonists. Indomethacin and ramatroban, which act, respectively, as an agonist and an antagonist, were the first nonprostanoid compounds to be identified as DP2 ligands. These two compounds have frequently used as leads for identifying new selective compounds1.
Alternative names: CRTH2/GPR44, Prostanoid DP2 receptor, Prostaglandin D2 receptor 2, PTGDR2, CD294 -
基因ID
- 309212
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NCBI登录号
- NM_004778
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UniProt
- Q6XKD3
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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