Prostacyclin Receptor 抗体 (Extracellular)
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- 抗原 See all Prostacyclin Receptor (PTGIR) 抗体
- Prostacyclin Receptor (PTGIR)
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抗原表位
- AA 290-302, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Prostacyclin Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Prostacyclin Receptor (PTGIR)
- 特异性
- 3rd extracellular loop
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse - identical, human - 11,13 amino acid residues identical
- 产品特性
- Anti-Prostacyclin Receptor (PTGIR) (extracellular) Antibody is directed against an epitope of rat the PGI2 receptor. Anti-Prostacyclin Receptor (PTGIR) (extracellular) Antibody (ABIN7043563, ABIN7045122 and ABIN7045123)) can be used in western blot analysis. The antibody recognizes an extracellular epitope, ideal for detecting the receptor in living cells. It has been designed to recognize PGI2 receptor from human, mouse and rat samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat PTGIR
- 亚型
- IgG
- Top Product
- Discover our top product PTGIR Primary Antibody
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anti-Prostacyclin Receptor (PTGIR) (AA 207-386) antibody
PTGIR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 296-386) antibodyPTGIR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 296-387) antibodyPTGIR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (N-Term) antibodyPTGIR 适用: 人, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) antibodyPTGIR 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Prostacyclin Receptor (PTGIR) (AA 198-247) antibodyPTGIR 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:400
- 说明
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Negative Control: BLP-PR068
Blocking Peptide: BLP-PR068
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Prostacyclin Receptor (PTGIR)
- 别名
- PTGIR (PTGIR 产品)
- 背景
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Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor,Prostaglandins comprise a family of locally acting hormones, whose synthesis is initiated by the enzyme COX. This pathway is involved in a broad variety of pathological conditions such as cancer, inflammation and hypertension.Prostaglandin I2 receptor (PGI2 receptor) is G-coupled protein receptor (GPCR) with seven hydrophobic transmembrane segments and an extracellular NH2 terminus. Prostaglandin receptors belong to family A, group V of GPCRs. There is significant ligand-binding cross-reactivity between different prostaglandins and different receptors in the family. Within the PG family, receptors share roughly 20-30 % of their sequence and there are 34 identical residues across the family. Twenty of these residues are unique to PG receptors and are not shared by other GPCRs. The unique residues reside mostly in the transmembrane region and in the second extracellular loop region. Both of these regions are implicated in ligand binding. The PGI2 receptor signals primarily via stimulation of cAMP generation but through PIP2 as well despite a much higher agonist concentration required for PIP2 hydrolysis.PGI2 receptor mRNA is highly expressed in the human heart, aorta, kidney, liver and lung tissues and in mice thymus, heart and spleen1. Mice lacking PGI2 receptor have been shown to have a reduced inflammation response and a significant decrease in clinical arthritis. In addition, human patients with a dysfunctional PGI2 receptor variant exhibit an enhanced atherothrombotic phenotype with higher incidence of triple vessel coronary disease and cardiovascular events2.
Alternative names: Prostacyclin Receptor (PTGIR), Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor - 基因ID
- 292661
- NCBI登录号
- NM_000960
- UniProt
- P43253
- 途径
- cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling
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