Prokineticin Receptor 2 抗体 (Extracellular)
Quick Overview for Prokineticin Receptor 2 抗体 (Extracellular) (ABIN7043561)
抗原
See all Prokineticin Receptor 2 (PROKR2) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 3-15, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Prokineticin Receptor 2
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特异性
- Extracellular, N-terminus
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预测反应
- Mouse - 11,13 amino acid residues identical, human - 9
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产品特性
- Anti-Prokineticin Receptor 2 (extracellular) Antibody is directed against an epitope located at the extracellular N-terminal domain of the rat Prokineticin receptor 2. The epitope is specific for PROKR2 and will not cross-react with the closely related PROKR1. Anti-Prokineticin Receptor 2 (extracellular) Antibody (ABIN7043561 and ABIN7045111) can be used in western blot and immunohistochemical applications. It has been designed to recognize PROKR2 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DQNGNTSFAPDLN, corresponding to amino acid residues 3-15 of rat PROKR2
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亚型
- IgG
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anti-Prokineticin Receptor 2 (PROKR2) antibody
PROKR2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (N-Term) antibodyPROKR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (Internal Region) antibodyVerified PROKR2 适用: 人, 大鼠 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (AA 121-136) antibodyPROKR2 适用: 人, 小鼠, 大鼠 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 6D3B9 unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (acetylated) antibodyPROKR2 适用: 人, 小鼠 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 4E9B11 unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (AA 1-45) antibodyPROKR2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (C-Term) antibodyPROKR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (N-Term) antibodyPROKR2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (N-Term) antibodyPROKR2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 2 (PROKR2) (C-Term) antibodyPROKR2 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236613)
Blocking Peptide: (ABIN7236613)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Prokineticin Receptor 2 (PROKR2)
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别名
- PROKR2
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背景
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PROKR2, PKR2, G-protein coupled receptor 73-like 1, Gpr73l1, Gpr73b, G-protein coupled receptor I5E,The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin receptor 1 (PKR1) and Prokineticin receptor 2 (PKR2) that belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR2 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.The distribution of PKR2 is relatively restricted with high expression levels in the brain, spinal cord and dorsal root ganglions, in organs of the reproductive system and in endocrine tissues such as the thyroid, pituitary and adrenal glands.1The PK2 ligand has been shown to be involved in the regulation of circadian rhythms of physiological and behavioral processes in mammals, probably through signaling via PKR2 which is highly expressed in the suprachiasmatic nucleus (SCN), an area of the brain that controls circadian rhythm processes.2In addition, loss-of-function mutations in the PKR2 gene have been associated with Kallmann Syndrome, a condition characterized by idiopathic hypogonadotropic hypogonadism (IHH) in combination with anosmia, a compromised sense of smell.3
Alternative names: Prokineticin Receptor 2, PROKR2, PKR2, G-protein coupled receptor 73-like 1, Gpr73l1, Gpr73b, G-protein coupled receptor I5E -
基因ID
- 192649
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NCBI登录号
- NM_144773
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UniProt
- Q8R415
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途径
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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