Prokineticin Receptor 1 抗体 (Extracellular, N-Term)
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Quick Overview for Prokineticin Receptor 1 抗体 (Extracellular, N-Term) (ABIN7043560)
抗原
See all Prokineticin Receptor 1 (PROKR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-24, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Prokineticin Receptor 1
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Unlikely to recognize human samples.
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预测反应
- Mouse - 12,15 amino acid residues identical
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产品特性
- Anti-Prokineticin Receptor 1 (extracellular) Antibody is directed against an epitope located at the extracellular N-terminal domain of the rat Prokineticin receptor 1. The epitope is specific for PROKR1 and will not cross-react with the closely related PROKR2. Anti-Prokineticin Receptor 1 (extracellular) Antibody (ABIN7043560 and ABIN7045110) can be used in western blot, immunohistochemistry and flow cytometry applications, and recognizes PROKR1 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ENTTNTFTDFFSARD, corresponding to amino acid residues 10-24 of rat PROKR1
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亚型
- IgG
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anti-Prokineticin Receptor 1 (PROKR1) (N-Term) antibody
PROKR1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) (N-Term) antibodyPROKR1 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) (N-Term) antibodyPROKR1 适用: 人 WB, FACS, EIA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) (N-Term) antibodyPROKR1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) (AA 1-62) antibodyPROKR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) antibodyPROKR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prokineticin Receptor 1 (PROKR1) (N-Term) antibodyPROKR1 适用: 人, 小鼠 ELISA, WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7236609)
Blocking Peptide: (ABIN7236609)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Prokineticin Receptor 1 (PROKR1)
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别名
- PROKR1
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背景
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Synonyms: PROKR1, PKR1, G-protein coupled receptor 73, Gpr73, Gpr73a, G-protein coupled receptor ZAQ
Description: The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin receptor 1 (PKR1) and Prokineticin receptor 2 (PKR2) that belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization. In addition, activation of the mitogen-activated protein kinase (MAPK) pathways has also been described.1PKR1 is broadly distributed throughout peripheral tissues including the intestinal tract, testis, uterus, lung and peripheral blood leukocytes. In addition, the receptor is expressed in the brain, particularly in olfactory regions, as well as in dorsal root ganglion (DRG) neurons.The physiological function of PKR1 is still being elucidated, however, evidence suggest that the receptor has an important role in pain perception through its ability to stimulate the TRPV1 ion channel in DRG neurons.2In addition, a role for PKR1 in the control of the inflammatory response through regulation of macrophage chemotaxis and cytokine production has also been demonstrated.3
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基因ID
- 192648
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NCBI登录号
- NM_138964
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UniProt
- Q8R416
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途径
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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