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- 抗原 See all KCNA3 抗体
- KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))
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抗原表位
- AA 263-276, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCNA3 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to KV1.3 (KCNA3) Channel Conjugated to the Fluorescent Dye Phycoerythrin
- 特异性
- Extracellular loop between domains S1 and S2.
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse - 12,14 amino acid residues identical
- 产品特性
- Anti-KV1.3 (KCNA3) (extracellular) Antibody (ABIN7043521, ABIN7044992 and ABIN7044993) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, live cell imaging and indirect flow cytometry applications. It has been designed to recognize KV1.3 potassium channel from human, mouse and rat samples. \nAnti-KV1.3 (KCNA3) (extracellular)-PE Antibody (ABIN7043524, ABIN7045648, ABIN7045649 and ABIN7045650) is directly conjugated to Phycoerythrin (PE). This labeled antibody can be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: KDYPASTSQDSFEA(C), corresponding to amino acid residues 263-276 of human KV1.3
- 亚型
- IgG
- Top Product
- Discover our top product KCNA3 Primary Antibody
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anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 424-523) antibody
KCNA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 263-276), (Extracellular) antibodyKO Validated KCNA3 适用: 人 WB, IHC, IF, FACS, IP, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 486-575) antibodyKCNA3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (C-Term) antibodyKCNA3 适用: 人, 大鼠, 小鼠, Pig, 兔, 犬, Hamster, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 101-150), (pTyr135) antibodyKCNA3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 263-276), (Extracellular) antibody (Biotin)KCNA3 适用: 人 WB, IHC, IF, FACS 宿主: 兔 Polyclonal Biotin
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) antibodyKCNA3 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (Ser67) antibodyKCNA3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 263-276), (Extracellular) antibodyKCNA3 适用: 人 WB, IHC, IF 宿主: 豚鼠 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
- 说明
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Negative Control: (ABIN7582046)
Blocking Peptide: (ABIN7236496)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))
- 别名
- KCNA3 (KCNA3 产品)
- 背景
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Potassium voltage-gated channel subfamily A member 3,KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. The prominence of KV1.3 channels in these cells (particularly in T lymphocytes) directed much research attention. It was found that KV1.3 is the main channel responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2 Based on the central role of KV1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1KV1.3 channels are potently inhibited by several venomous peptide toxins among them Charybdotoxin (2.6 nM), Noxiustoxin (1 nM), Kaliotoxin (0.65 nM), Margatoxin (0.05 nM), Agitoxin-1 (1.7 nM), Agitoxin-2 (0.004 nM), Hongotoxin-1 (0.09 nM) and Stichodactyla toxin (0.01 nM).3-7The central role of KV1.3 in immune system cells created a real need for a specific antibody that would be able to work in flow cytometry applications.
Alternative names: KV1.3 (KCNA3), Potassium voltage-gated channel subfamily A member 3 - 基因ID
- 3738
- NCBI登录号
- NM_002232
- UniProt
- P22001
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