KCNA1 抗体 (Extracellular)
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Quick Overview for KCNA1 抗体 (Extracellular) (ABIN7043514)
抗原
See all KCNA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 193-206, Extracellular
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原理
- A Rabbit Polyclonal Antibody to KV1.1 (KCNA1) Channel
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特异性
- 1st extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-KV1.1 (KCNA1) (extracellular) Antibody (ABIN7043514, ABIN7045058 and ABIN7045059) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, indirect flow cytometry and live cell imaging applications. It has been designed to recognize KV1.1 from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KDDKDFTGTIHRID, corresponding to amino acid residues 193-206 of rat KV1.1
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亚型
- IgG
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anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 7-150) antibody
KCNA1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) antibodyKCNA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 410-495) antibodyKCNA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D8 unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 1-495) antibodyKCNA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 193-206), (Extracellular) antibody (Atto 594)KCNA1 适用: 大鼠 IHC, IF, IC, LCI 宿主: 兔 Polyclonal Atto 594
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) antibodyKCNA1 适用: 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 256-305) antibodyKCNA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 179-228) antibodyKCNA1 适用: 人, 犬, Pig, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (Middle Region) antibodyKCNA1 适用: 人, 大鼠, 小鼠, 犬, Pig, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236476)
Blocking Peptide: (ABIN7236476)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
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别名
- KCNA1
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背景
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Potassium voltage-gated channel subfamily A member 1,KV1.1 is a mammalian voltage-dependent K+ channel, homologous to the Drosophila Shaker K+ channel. KV1.1 was the first mammalian KV channel to be cloned from mouse brain.1 Eight Shaker-related genes exist in mammals constituting the KV1, subfamily of the large KV channel family of genes.2A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function. The structure of KV1.1 channel is similar to all KV channels and includes six membrane spanning helices creating a voltage sensor domain and a pore domain.2The channel is expressed in neurons and cardiac and skeletal muscle tissue as well as in the retina and pancreas.2 The functional channel is considered low voltage activated and shows very little inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle. Mutations in the coding of KV1.1 gene were discovered in Episodic Ataxia patients.3KV1.1 channels are sensitive to low doses of TEA (0.3 mM) and 4-AP (0.29 mM), the "classical" non-selective potassium channel blockers.Several venomous toxins from snakes, scorpions and sea anemones are potent blockers (affecting the channels in the nanomolar range) of KV1.1 channels. Among these, the most potent and selective are α-Dendrotoxin (0.4-4 nM) and δ-Dendrotoxin (0.03-1.8 nM), Dendrotoxin-K (0.03 nM), Agitoxin-2 (0.044 nM) and Hongotoxin-1 (0.031 nM).4
Alternative names: KV1.1 (KCNA1), Potassium voltage-gated channel subfamily A member 1 -
基因ID
- 24520
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NCBI登录号
- NM_000217
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UniProt
- P10499
抗原
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