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KCNA1 抗体 (Extracellular)

Name: KCNA1 抗体 (Extracellular)
SKU: ABIN1304744
Availability: OutOfStock

There are 28+ publications for this product available. The 小鼠单克隆 anti-KCNA1 antibody is suitable to detect KCNA1 in samples from 大鼠. It has been validated for WB, ELISA, IHC 和 ICC.

(28 references)

产品编号 ABIN1304744

发货至: 中国

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Quick Overview for KCNA1 抗体 (Extracellular) (ABIN1304744)

抗原

See all KCNA1 抗体

KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

适用

大鼠

宿主

小鼠

克隆类型

单克隆

标记

This KCNA1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

质量等级

KO Validated

克隆位点

K36-15

Discover our top product KCNA1 Primary Antibody

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AA 191-208, Extracellular

原理

Anti-Kv1.1 K+ Channel (External) Antibody

序列

ELKDDKDFTG TIHRIDNTC

特异性

No off-targets reported

交叉反应

小鼠

产品特性

Our Anti-Kv1.1 K+ channel (external) mouse monoclonal primary antibody is produced in-house from hybridoma clone K36/15. It is KO validated, detects mouse and rat Kv1.1 K+ channel (external), and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

纯化方法

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

纯度

Purified mAbs are >90 % specific antibody.

免疫原

Synthetic peptide amino acids 191-208 (ELKDDKDFTGTIHRIDNTC, extracellular domain) of rat Kv1.1 (accession number P10499)

亚型

IgG2b
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 7-150) antibody
KCNA1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) antibody
KCNA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 410-495) antibody
KCNA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D8 unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 1-495) antibody
KCNA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 193-206), (Extracellular) antibody
KCNA1 适用: 大鼠 WB, IF, IC, LCI, FACS 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 193-206), (Extracellular) antibody (Atto 594)
KCNA1 适用: 大鼠 IHC, IF, IC, LCI 宿主: 兔 Polyclonal Atto 594

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) antibody
KCNA1 适用: 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 256-305) antibody
KCNA1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (AA 179-228) antibody
KCNA1 适用: 人, 犬, Pig, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (Middle Region) antibody
KCNA1 适用: 人, 大鼠, 小鼠, 犬, Pig, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide 7.4

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

有效期

24 months
Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).

Zollinger, Chang, Baalman, Kim, Rasband: "The Polarity Protein Pals1 Regulates Radial Sorting of Axons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 29, pp. 10474-84, (2015) (PubMed).

Sosanya, Brager, Wolfe, Niere, Raab-Graham: "Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis." in: Neurobiology of disease, Vol. 73, pp. 96-105, (2014) (PubMed).

Jones, Corbin, Huntsman: "Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia." in: PLoS ONE, Vol. 9, Issue 10, pp. e109303, (2014) (PubMed).

Hoppa, Gouzer, Armbruster, Ryan: "Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals." in: Neuron, Vol. 84, Issue 4, pp. 778-89, (2014) (PubMed).

Kirizs, Kerti-Szigeti, Lorincz, Nusser: "Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells." in: The European journal of neuroscience, Vol. 39, Issue 11, pp. 1771-83, (2014) (PubMed).

Desmazieres, Zonta, Zhang, Wu, Sherman, Brophy: "Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 15, pp. 5083-8, (2014) (PubMed).

Dufour, Woodhouse, Goaillard: "Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development." in: Journal of neuroscience research, Vol. 92, Issue 8, pp. 981-99, (2014) (PubMed).

Campanac, Gasselin, Baude, Rama, Ankri, Debanne: "Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits." in: Neuron, Vol. 77, Issue 4, pp. 712-22, (2013) (PubMed).

Lallet-Daher, Wiel, Gitenay, Navaratnam, Augert, Le Calvé, Verbeke, Carling, Aubert, Vindrieux, Bernard: "Potassium channel KCNA1 modulates oncogene-induced senescence and transformation." in: Cancer research, Vol. 73, Issue 16, pp. 5253-65, (2013) (PubMed).

Sosanya, Huang, Cacheaux, Chen, Nguyen, Perrone-Bizzozero, Raab-Graham: "Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1." in: The Journal of cell biology, Vol. 202, Issue 1, pp. 53-69, (2013) (PubMed).

Kyle, Ahrendt, Braun, Braun: "The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein." in: Scientific reports, Vol. 3, pp. 2447, (2013) (PubMed).

Liu, Lee, Davis: "Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels." in: Neuroscience, Vol. 257, pp. 96-110, (2013) (PubMed).

Bildl, Haupt, Müller, Biniossek, Thumfart, Hüber, Fakler, Schulte: "Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 2, pp. M111.007955, (2012) (PubMed).

Li, Lu, Xu, Zhang, Zhu, Zhang, Cao, Chen, Chen, Luo, Duan, Li: "Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy." in: Nature neuroscience, Vol. 15, Issue 2, pp. 267-73, (2012) (PubMed).

Bangratz, Sarrazin, Devaux, Zambroni, Echaniz-Laguna, René, Boërio, Davoine, Fontaine, Feltri, Benoit, Nicole et al.: "A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is ..." in: The American journal of pathology, Vol. 180, Issue 5, pp. 2040-55, (2012) (PubMed).

Irani, Pettingill, Kleopa, Schiza, Waters, Mazia, Zuliani, Watanabe, Lang, Buckley, Vincent: "Morvan syndrome: clinical and serological observations in 29 cases." in: Annals of neurology, Vol. 72, Issue 2, pp. 241-55, (2012) (PubMed).

Zhu, Alsaber, Zhao, Ribeiro-Hurley, Thornhill: "Characterization of the Kv1.1 I262T and S342I mutations associated with episodic ataxia 1 with distinct phenotypes." in: Archives of biochemistry and biophysics, Vol. 524, Issue 2, pp. 99-105, (2012) (PubMed).

Menegola, Clark, Trimmer: "The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice." in: Epilepsia, Vol. 53 Suppl 1, pp. 142-9, (2012) (PubMed).

Giacomini, La Padula, Schenone, Leandri, Contestabile, Moruzzo, Goutebroze, Consalez, Benfenati, Corradi: "Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice." in: Neurobiology of disease, Vol. 42, Issue 1, pp. 73-84, (2011) (PubMed).

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抗原

KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

别名

Kv1.1 K+ channel

背景

Synonyms: Potassium voltage-gated channel subfamily A member 1 (RBKI) (RCK1) (Voltage-gated potassium channel subunit Kv1.1)
Description Logic: Our Anti-Kv1.1 K+ channel (external) mouse monoclonal primary antibody is produced from hybridoma clone K36/15. It is KO validated, detects mouse and rat Kv1.1 K+ channel (external), and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.
Gene Name Alternatives: Kcna1

分子量

56 kDa (could be 65-85 kDa depending on glycosylation)

UniProt

P10499