KCNK1 抗体 (Extracellular)
Quick Overview for KCNK1 抗体 (Extracellular) (ABIN7043443)
抗原
See all KCNK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 53-69, Extracellular
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原理
- A Rabbit Polyclonal Antibody to KCNK1 Channel
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特异性
- Extracellular, near the P1 loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse,pig - identical
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产品特性
- Anti-KCNK1 (extracellular) Antibody is directed against an epitope of the human K2P1.1 channel. Anti-KCNK1 (extracellular) Antibody (ABIN7043443, ABIN7045008 and ABIN7045009) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1
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亚型
- IgG
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anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 268-336) antibody
KCNK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (N-Term) antibodyKCNK1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 265-336) antibodyKCNK1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4D7 unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (C-Term) antibodyKCNK1 适用: 人, 小鼠, 兔, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 293-320), (C-Term) antibodyKCNK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32239 unconjugated
anti-Potassium Channel Subfamily K Member 1 (KCNK1) (AA 300-328), (C-Term) antibodyKCNK1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:300
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说明
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Negative Control: (ABIN7236284)
Blocking Peptide: (ABIN7236284)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))
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别名
- KCNK1
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背景
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Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1,KCNK1 (also named TWIK-1 or K2P1.1) is a member of the 2-pore (2P) domain K+ channels family that, currently, includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers.KCNK1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart.
Alternative names: KCNK1 (TWIK-1), Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1 -
基因ID
- 3775
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NCBI登录号
- NM_002245
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UniProt
- O00180
抗原
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