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- 抗原 See all Otopetrin 1 (OTOP1) 抗体
- Otopetrin 1 (OTOP1)
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抗原表位
- AA 374-388
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Otopetrin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Otopetrin-1 Channel
- 特异性
- 4th intracellular loop.
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,human - identical
- 产品特性
- Anti-OTOP1 Antibody (ABIN7043417, ABIN7044503 and ABIN7044504)) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Otopetrin-1 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EKSLDESKNPARKLD, corresponding to amino acid residues 374 - 388 of mouse Otopetrin-1
- 亚型
- IgG
- Top Product
- Discover our top product OTOP1 Primary Antibody
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anti-Otopetrin 1 (OTOP1) (AA 415-504) antibody
OTOP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E3 unconjugated
anti-Otopetrin 1 (OTOP1) (AA 414-544) antibodyOTOP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Otopetrin 1 (OTOP1) (AA 360-388) antibodyOTOP1 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29945 unconjugated
anti-Otopetrin 1 (OTOP1) (AA 367-396), (Middle Region) antibodyOTOP1 适用: 小鼠, 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-HC005
Blocking Peptide: BLP-HC005
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Otopetrin 1 (OTOP1)
- 别名
- OTOP1 (OTOP1 产品)
- 背景
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Proton Channel OTOP1, Otopetrin-1,Otopetrin-1 (Otop-1) is a proton channel involved in sour taste recognition. It belongs to the Otopetrin proton channel family together with Otopetrins-2 and 31. Otop-1 is a dimeric structure, with each subunit forming 12 transmembrane helices divided into structurally similar N- and C-domains2.Taste recognition is very important because it enables to sample chemicals in the environment prior to digestion and hence, plays an important role in feeding and avoiding intoxication2. The sense of sour taste is caused by acids, and the first step in sour taste transduction is an influx of H+ ions through Otop-1 channel into the type three Taste Receptor Cells (TRCs). This leads to a decrease in intracellular pH and operation of a signaling cascade1-3.Otop-1 is specifically expressed in type three taste cells and exhibits the Zn2+ sensitivity that is a key feature observed in the proton current of sour taste cells4.Otop-1 also has a role in regulating intracellular Ca2+ levels required for the formation of otoconia in the vertebrate inner ear. Otoconia are complex calcium carbonate biominerals required for the sensation of gravity5.
Alternative names: Proton Channel OTOP1, Otopetrin-1 - 基因ID
- 21906
- NCBI登录号
- NM_177998
- UniProt
- Q80VM9
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