OPRK1 抗体 (Extracellular)
Quick Overview for OPRK1 抗体 (Extracellular) (ABIN7043402)
抗原
See all OPRK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-55, Extracellular
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原理
- A Rabbit Polyclonal Antibody to ?-Opioid Receptor (OPRK1)
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- human - 15,17 amino acid residues identical,Mouse -16
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产品特性
- Anti-κ-Opioid Receptor (OPRK1) (extracellular) Antibody is directed against an epitope of the rat κ-opioid receptor. Anti-κ-Opioid Receptor (OPRK1) (extracellular) Antibody (ABIN7043402, ABIN7044889 and ABIN7044890) can be used in western blot analysis. The antibody recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. The antibody was designed to recognize κ-opioid receptor from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)NGSVGSEDQQLEPAHIS, corresponding to amino acid residues 39-55 of rat kappa-Opioid receptor
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亚型
- IgG
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anti-Opioid Receptor, kappa 1 (OPRK1) (C-Term) antibody
OPRK1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (AA 1-58) antibodyOPRK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (pSer369) antibodyOPRK1 适用: 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (AA 31-50) antibodyOPRK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (AA 181-209) antibodyOPRK1 适用: 人 WB 宿主: 兔 Polyclonal RB42653 unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (pSer369) antibodyOPRK1 适用: 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (Extracellular Domain) antibodyOPRK1 适用: 人, 大鼠, 猴, 犬, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (N-Term) antibodyOPRK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) antibodyOPRK1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, kappa 1 (OPRK1) (C-Term) antibodyVerified OPRK1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7236171)
Blocking Peptide: (ABIN7236171)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- OPRK1 (Opioid Receptor, kappa 1 (OPRK1))
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别名
- OPRK1
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背景
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Kappa-type opioid receptor, KOR-1, Opiate receptor kappa 1,Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (μ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor1. Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic μ, δ, and κ receptors2.The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins1.All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the μ-opioid receptor, whereas μ-, δ-, and κ-receptors participate in the control of pain at the spinal level3. The opioid receptors also mediate the mood-altering properties of opioids4.κ-Opioid Receptor is activated by the endogenous peptide dynorphin. Malfunction of their signaling may be involved in epilepsy, addiction, depression, schizophrenia, and chronic pain5.κ-Opioid Receptor is localized to a number of regions in the brain, as well as the spinal cord, the enteric nervous system and the digestive system5.
Alternative names: Kappa-Opioid Receptor (OPRK1), Kappa-type opioid receptor, KOR-1, Opiate receptor kappa 1 -
基因ID
- 29335
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NCBI登录号
- NM_000912
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UniProt
- P34975
抗原
-
