OPRD1 抗体 (Extracellular)
Quick Overview for OPRD1 抗体 (Extracellular) (ABIN7043401)
抗原
See all OPRD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-18, Extracellular
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原理
- A Rabbit Polyclonal Antibody to ?-Opioid Receptor (OPRD1)
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Will not recognize human samples.
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预测反应
- Rat - 13,17 amino acid residues identical
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产品特性
- Anti-δ-Opioid Receptor (OPRD1) (extracellular) Antibody (ABIN7043401, ABIN7044891 and ABIN7044892) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. The antibody recognizes an extracellular epitope and can potentially detect the receptor in living cells. The antibody is designed to recognize from mouse and rat samples. It will not recognize from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)ELVPSARAELQSSPLVN corresponding to amino acid residues 2-18 of mouse delta-Opioid receptor
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亚型
- IgG
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anti-Opioid Receptor, delta 1 (OPRD1) (AA 81-180) antibody
OPRD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) (pSer363) antibodyOPRD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) (C-Term) antibodyOPRD1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) antibodyOPRD1 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 7G7 unconjugated Recombinant Antibody
anti-Opioid Receptor, delta 1 (OPRD1) (C-Term) antibodyOPRD1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) (Extracellular Domain) antibodyOPRD1 适用: 人, 猴, 犬, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) (C-Term) antibodyOPRD1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, delta 1 (OPRD1) (AA 323-372), (pSer363) antibodyOPRD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- OPRD1 (Opioid Receptor, delta 1 (OPRD1))
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别名
- OPRD1
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背景
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DOR-1,Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (μ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor.1 Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic μ, δ, and κ receptors.2The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins.1All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the μ-opioid receptor, whereas μ-, δ-, and κ-receptors participate in the control of pain at the spinal level.3 The opioid receptors also mediate the mood-altering properties of opioids.4 Cross-talk between μ- and δ- opioid receptors was demonstrated when subeffective doses of d-opioid receptors agonists modulated m-mediated analgesia.5The δ receptors are discretely distributed in the central nervous system (CNS), with a prominent gradient of receptor density from high levels in forebrain structures to relatively low levels in most hindbrain regions.2
Alternative names: delta-Opioid Receptor (OPRD1), DOR-1 -
基因ID
- 18386
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NCBI登录号
- NM_000911
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UniProt
- P32300
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途径
- Protein targeting to Nucleus
抗原
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