O3FAR1 抗体 (Extracellular)
Quick Overview for O3FAR1 抗体 (Extracellular) (ABIN7043397)
抗原
See all O3FAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-36, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Free Fatty Acid Receptor 4 (GPR120)
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, human - 14,15 amino acid residues identical
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产品特性
- Anti-GPR120/FFAR4 (extracellular) Antibody (ABIN7043397, ABIN7044281 and ABIN7044282) is a highly specific antibody directed against an epitope of the mouse Free fatty acid receptor 4. The antibody can be used in western blot and indirect live cell flow cytometry. It has been designed to recognize FFAR4 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RTHFPFFSDVKGDHR, corresponding to amino acid residues 22-36 of mouse FFAR4
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亚型
- IgG
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anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (N-Term) antibody
O3FAR1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) antibodyO3FAR1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (AA 247-258) antibodyO3FAR1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (C-Term) antibodyO3FAR1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (Internal Region) antibodyO3FAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (Internal Region) antibodyO3FAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (Internal Region) antibodyVerified O3FAR1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (AA 243-292) antibodyO3FAR1 适用: 人, 小鼠, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) (AA 221-270) antibodyO3FAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7236163)
Blocking Peptide: (ABIN7236163)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))
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别名
- FFAR4
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背景
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G-protein coupled receptor 120, Free fatty acid receptor 4, FFA4 Receptor, G-protein coupled receptor GT01, Omega-3 fatty acid receptor 1, O3far1,Free fatty acid receptor 4 (FFAR4, GPR120), is a member of the rhodopsin family of 7-transmembrane domain G-protein coupled receptors (GPCRs). GPR120/FFAR4 is activated by long chain fatty acids. The protein is a potential therapeutic target for the treatment of type 2 diabetes mellitus (T2DM). GPR120 is associated to insulin sensitizing, anti-inflammatory, and fat metabolism. Evidence shows that GPR120 may be involved in the development of obesity in mice and humans1-4. GPR120 regulates various physiological processes, including gut hormone secretion, islet function, osteoclastogenesis, anti-inflammation, and adipogenesis2-4.GPR120 binds to omega-3 fatty acids and stabilizes the metabolic homeostasis through a cascade of physiological activities. GPR120 exerts its physiological effects through one of two pathways that involves either Gαq or β-arrestin2,3.GPR120 has been shown to be ubiquitously expressed and is primarily detected in the intestine, adipocytes, and pro-inflammatory macrophages1,2.
Alternative names: GPR120/FFAR4 (extracellular), GPR120, FFA4 Receptor , Free fatty acid receptor 4, Omega-3 fatty acid receptor 1, G-protein coupled receptor 120, G-protein coupled receptor GT01, O3far1 -
基因ID
- 107221
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NCBI登录号
- NM_181745
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UniProt
- Q7TMA4
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途径
- Hormone Transport
抗原
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