NTSR2 抗体 (Intracellular)
Quick Overview for NTSR2 抗体 (Intracellular) (ABIN7043384)
抗原
See all NTSR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 377-392, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Neurotensin Receptor 2
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特异性
- Intracellular, C-terminus
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Unlikely to recognize human samples.
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预测反应
- Mouse - 14,16 amino acid residues identical
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产品特性
- Anti-Neurotensin Receptor 2 Antibody is directed against an epitope at the intracellular C-terminal domain of the rat Neurotensin receptor type 2. Anti-Neurotensin Receptor 2 Antibody (ABIN7043384, ABIN7044769 and ABIN7044770) can be used in western blot, immunohistochemical and immunocytochemical applications, and recognizes NTR2 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2
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亚型
- IgG
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anti-Neurotensin Receptor 2 (NTSR2) (AA 359-410) antibody
NTSR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (C-Term) antibodyNTSR2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (Extracellular Domain) antibodyNTSR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (Internal Region) antibodyNTSR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (AA 151-200) antibodyNTSR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50-1:100
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Cited Application: IHC
Negative Control: (ABIN7236129)
Blocking Peptide: (ABIN7236129)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NTSR2 (Neurotensin Receptor 2 (NTSR2))
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别名
- NTSR2
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背景
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NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor,Neurotensin receptor 2 (NTR2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR2 and NTR1 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+mobilization. However, the exact signaling mechanisms subsequent to NTR2 activation appear to depend on the species and on the cellular system in which the receptor is studied.NTR2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion.2The most established physiological role of NTR2 is its role in pain transmission as NTR2-defficient mice showed that NTR2 is the likely mediator of the neurotensin-induced analgesic responses.3
Alternative names: Neurotensin Receptor 2, NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor -
基因ID
- 64636
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NCBI登录号
- NM_012344
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UniProt
- Q63384
抗原
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