NMUR2 抗体 (Extracellular)
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- 抗原 See all NMUR2 抗体
- NMUR2 (Neuromedin U Receptor 2 (NMUR2))
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抗原表位
- AA 3-16, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NMUR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Neuromedin-U Receptor 2
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- 14 amino acid residues identical,Mouse -13, human - 7
- 产品特性
- Anti-NMUR2 (extracellular) Antibody (ABIN7043366, ABIN7044706 and ABIN7044707)) is a highly specific antibody directed against an epitope of the rat Neuromedin-U receptor 2. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize NMUR2 from rat, human, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KLENASWIHDPLMK, corresponding to amino acid residues 3-16 of rat NMUR2
- 亚型
- IgG
- Top Product
- Discover our top product NMUR2 Primary Antibody
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anti-Neuromedin U Receptor 2 (NMUR2) (Cytoplasmic Domain) antibody
NMUR2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (C-Term) antibodyNMUR2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (AA 1-50) antibodyNMUR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (AA 326-415) antibodyNMUR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (N-Term) antibodyNMUR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-NR072
Blocking Peptide: BLP-NR072
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- NMUR2 (Neuromedin U Receptor 2 (NMUR2))
- 别名
- NMUR2 (NMUR2 产品)
- 背景
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Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72,Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1 (NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A GPCR family and share about 50 % identity with each other in the seven transmembrane region.NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5.Central effects of NMU, including the regulation of food intake, energy balance, stress response, and nociception, are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 has been suggested as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5.Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2.
Alternative names: NMUR2, Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72 - 基因ID
- 64042
- NCBI登录号
- NM_020167
- UniProt
- Q9ESQ4
- 途径
- Feeding Behaviour
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