NFASC 抗体 (C-Term, Intracellular)
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Quick Overview for NFASC 抗体 (C-Term, Intracellular) (ABIN7043360)
抗原
See all NFASC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1142-1155, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Neurofascin
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Neurofascin Antibody (ABIN7043360, ABIN7044538 and ABIN7044539) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize NFASC from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)REKKDVPLGPEDPK, corresponding to amino acid residues 1142-1155 of rat NFASC
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亚型
- IgG
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anti-Neurofascin (NFASC) (AA 501-650) antibody
NFASC 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 830-1100) antibodyNFASC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 661-758) antibodyNFASC 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neurofascin (NFASC) (C-Term) antibodyNFASC 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 760-1007) antibodyNFASC 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:800
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236045)
Blocking Peptide: (ABIN7236045)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NFASC (Neurofascin (NFASC))
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别名
- NFASC
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背景
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Synonyms: NFASC, NRCAML, NF
Description: Neurofascin belongs to the L1 subgroup of the immunoglobulin superfamily of cell adhesion molecules and is an axon associated surface glycoprotein implicated in axonal growth and fasciculation.Neurofascin is comprised of four structural elements: At the NH2 terminus, neurofascin contains six Ig-like motifs of the C2 subcategory followed by four fibronectin type III (FNIII)-related repeats. Between the FNIII-like repeats and the plasma membrane spanning region, neurofascin contains a 75-amino acid residues rich in proline, alanine and threonine which might be the target of extensive O-linked glycosylation. A transmembrane segment is followed by a 113-amino acid residues-long cytoplasmic domain1.Neurofascin associates with sodium channel β1 (NaVβ1) units via interaction of its first Ig-like domain and second fibronectin type III-like domain with the extracellular Ig-like domain of β1. NaVβ1 subunits localize to nodes of Ranvier with neurofascin in sciatic nerve axons. NaVβ1 and neurofascin are associated as early as postnatal day 5, during the period that nodes of Ranvier are in formation2.Unlike L1 and other subgroup members, neurofascin is subjected to extensive alternative splicing that is regulated during embryonic development of the brain. An oligodendroglial isoform of neurofascin, NF155, serves as a glial receptor for the paranodin/Caspr-contactin complex. The extracellular domain of NF155 binds to the complex at the cell surface3.
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基因ID
- 116690
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NCBI登录号
- NM_001005388
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UniProt
- P97685
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途径
- Cell-Cell Junction Organization
抗原
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