PVRL2 抗体 (Extracellular)
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Quick Overview for PVRL2 抗体 (Extracellular) (ABIN7043340)
抗原
See all PVRL2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 148-161, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Nectin-2/PVRL2
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, human - 10,14 amino acid residues identical
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产品特性
- Anti-Nectin-2/PVRL2 (extracellular) Antibody is directed against an epitope of mouse Poliovirus receptor-related protein 2. Anti-Nectin-2/PVRL2 (extracellular) Antibody (ABIN7043340, ABIN7044694 and ABIN7044695) can be used in western blot, immunohistochemistry, and flow cytometry applications. It has been designed to recognize Nectin-2 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RVIAQPENHAEAQE, corresponding to amino acid residues 148-161 of mouse Nectin-2
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亚型
- IgG
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anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 76-353) antibody
PVRL2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2A6-2C1 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 58-212) antibodyPVRL2 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4A11B12 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 251-350) antibodyPVRL2 适用: 人 WB, FACS, ELISA, ICC, IF (p), IHC (fro), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 83-291) antibodyPVRL2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) antibodyPVRL2 适用: 人 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal R2-525 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) antibody (PE)PVRL2 适用: 人 FACS 宿主: 小鼠 Monoclonal R2-525 PE
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) antibodyPVRL2 适用: 人 FACS, ELISA, IP 宿主: 小鼠 Monoclonal B-C12 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:600
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IP
Negative Control: (ABIN7235990)
Blocking Peptide: (ABIN7235990)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
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别名
- NECTIN2
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背景
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Poliovirus receptor-related protein 2, Herpes virus entry mediator B, PRR2, PVRR2, CD112,The Nectin family is known as cell-cell adhesion molecules and comprises four members in this family: nectin-1, nectin-2, nectin-3 and nectin-4 which are encoded by PVRL1, PVRL2, PVRL3, and PVRL4 genes respectively1. They are Ca2+-independent immunoglobulin-like CAMs and are able to trans-interact1.They are localized at adherens junctions between two neighboring cells and binds to afadin through their C-terminal region1.Nectins, apart from a secreted nectin-1γ, exhibit three immunoglobulin-like loops (one V type and two C2 type) in their extracellular region, a single trans membrane segment and a cytoplasmic tail. Nectins first form a cis-homo-dimer which later on undergoes lateral cluster formation on the cell surface1. Nectins regulate a variety of cellular functions in addition to cell-cell junction formation such as cell polarity, movement, proliferation, differentiation, and survival1.The PVRL2 gene (which encodes nectin-2) encodes two mRNA isoforms of 3 kb and 4.4 kb both widely expressed in various human tissues including hematopoietic cells of the myelo-monocytic and megakaryocytic lineages and detected also on the surface of endothelial cells2.Nectin-2 acts as mediator of herpes simplex virus invasion into host cell. A single nucleotide polymorphism in PVRL2 shows an association with later onset of Alzheimers Disease3.
Alternative names: Nectin-2/PVRL2, Poliovirus receptor-related protein 2, Herpes virus entry mediator B, PRR2, PVRR2, CD112 -
基因ID
- 19294
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NCBI登录号
- NM_002856
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UniProt
- P32507
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
抗原
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