MC5 Receptor 抗体 (AA 224-236)
Quick Overview for MC5 Receptor 抗体 (AA 224-236) (ABIN7043325)
抗原
See all MC5 Receptor (MC5R) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 224-236
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原理
- A Rabbit Polyclonal Antibody to Melanocortin Receptor 5
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特异性
- 3rd intracellular loop
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat - 12,13 amino acid residues identical, human - 7
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产品特性
- Anti-MC5 Receptor Antibody is directed against an epitope of the mouse melanocortin receptor 5. Anti-MC5 Receptor Antibody (ABIN7043325 and ABIN7044598) can be used in western blot and immunohistochemical applications. It has been designed to recognize MC5R from mouse, human and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RYNSVRQRTSMKG, corresponding to amino acid residues 224-236 of mouse MC5R
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亚型
- IgG
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anti-Melanocortin 5 Receptor (MC5R) (AA 1-37) antibody
MC5R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (AA 78-125) antibodyMC5R 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (C-Term) antibodyMC5R 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (N-Term) antibodyVerified MC5R 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (C-Term) antibodyMC5R 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (AA 261-288), (C-Term) antibodyMC5R 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) antibodyMC5R 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (C-Term) antibodyMC5R 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) (N-Term) antibodyMC5R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 5 Receptor (MC5R) antibodyMC5R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235932)
Blocking Peptide: (ABIN7235932)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- MC5 Receptor (MC5R) (Melanocortin 5 Receptor (MC5R))
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别名
- MC5R
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背景
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Melanocortin receptor 5, MC5R, MC5-R,Melanocortin receptor 5 (MC5R) is one of five members of the melanocortin receptor family, which belongs to the 7-transmembrane domain, G-Protein Coupled Receptor (GPCR) superfamily.The ligands of these receptors, the melanocortins, are a group of structurally-related peptides comprising the α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and the adrenocorticotropic hormone (ACTH), all of which are derived from post-translational processing of a common precursor peptide, proopiomelanocortin (POMC) 1,2,3.One of the salient features of the melanocortin signaling system is the existence of two endogenous antagonists, proteins that bind specifically to the receptor and have an inhibitory effect. These antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP) 1.All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti/ASP and AGRP) with differing affinities. The order of potency for MC5R activation is α-MSH > ACTH = β-MSH >> γ-MSH while AGRP works as an endogenous antagonists of MC5R1,2,3.MC5R is mostly expressed in peripheral tissues such as skeletal muscle, bone marrow, skin tissues particularly in sebaceous glands and exocrine glands such as salivary glands1.The best understood function of Melanocortin Receptor 5 is in the regulation of exocrine glands since MC5R-deficient mice exhibit severely defective water repulsion and thermoregulation due to decreased production of sebaceous lipids4.
Alternative names: MC5 Receptor, Melanocortin receptor 5, MC5R, MC5-R -
基因ID
- 17203
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NCBI登录号
- NM_005913
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UniProt
- P41149
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途径
- cAMP Metabolic Process
抗原
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