Leukotriene B4 Receptor/BLT 抗体 (2nd Extracellular Loop)
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Quick Overview for Leukotriene B4 Receptor/BLT 抗体 (2nd Extracellular Loop) (ABIN7043307)
抗原
See all Leukotriene B4 Receptor/BLT (LTB4R) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 168-181
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原理
- A Rabbit Polyclonal Antibody to BLT1
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交叉反应 （详细）
- Not recommended for use with rat and mouse samples.
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预测反应
- Monkey - identical
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产品特性
- Anti-Human BLT1 (extracellular) Antibody (ABIN7043307 and ABIN7044557) is a highly specific antibody directed against an extracellular epitope of the human Leukotriene B4 receptor 1. The antibody can be used for western blot and indirect flow cytometry applications. It has been designed to recognize LTB4R from human samples only.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CFPRYPSEGHRAFH, corresponding to amino acid residues 168-181 of human LTB4R
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亚型
- IgG
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anti-Leukotriene B4 Receptor (LTB4R) (AA 101-200) antibody
LTB4R 适用: 人, 小鼠, 大鼠 FACS, IHC (fro), IHC (p), ELISA, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Leukotriene B4 Receptor (LTB4R) (Cytoplasmic Domain) antibodyLTB4R 适用: 人, 小鼠, 大鼠, 猴, Hamster, 马, 兔 IHC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leukotriene B4 Receptor (LTB4R) antibodyLTB4R 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leukotriene B4 Receptor (LTB4R) (C-Term) antibodyLTB4R 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leukotriene B4 Receptor (LTB4R) (AA 250-299) antibodyLTB4R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Leukotriene B4 Receptor (LTB4R) antibodyLTB4R 适用: 人 WB 宿主: 兔 Monoclonal 24GB50 unconjugated Recombinant Antibody
anti-Leukotriene B4 Receptor (LTB4R) antibodyLTB4R 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 1:25
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Leukotriene B4 Receptor/BLT (LTB4R) (Leukotriene B4 Receptor (LTB4R))
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别名
- LTB4R
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背景
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Synonyms: Leukotriene B4 receptor 1, LTB4R, LTB4R1, CMKRL1, GPR16, P2Y7, P2RY7
Description: Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB41. LTB4, a chemoattractant, plays a prominent role in the recruitment and activation of leukocytes2.LTB4 acts through two receptors which belong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells3 and is expressed to much lower levels in the spleen, thymus, heart, skeletal muscle, brain and liver2-4. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB45. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in the spleen, liver, ovary, and leukocytes2,5-8. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors2. However, activation of BLT1 usually correlates with increasing intracellular concentrations of Ca2+.The LTB4/BLT1 system is involved in many allergic reactions as well as asthma induced as an allergic response, where it plays a significant role in recruiting neutrophils and effector T cells into lungs as part of an inflammatory response induced by allergens1.
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基因ID
- 1241
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NCBI登录号
- NM_001143919
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UniProt
- Q15722
抗原
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