LRRTM1 抗体 (Extracellular)
Quick Overview for LRRTM1 抗体 (Extracellular) (ABIN7043302)
抗原
See all LRRTM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 334-346, Extracellular
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原理
- A Rabbit Polyclonal Antibody to LRRTM1
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- rat - 12,Mouse,13 amino acid residues identical, human - 11
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产品特性
- Anti-LRRTM1 (extracellular) Antibody (ABIN7043302, ABIN7044730 and ABIN7044731) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect the protein in living cells. It has been designed to recognize LRRTM1 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GRYDANLQ(S)ASPE, corresponding to amino acid residues 334-346 of mouse LRRTM1
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亚型
- IgG
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anti-Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) (AA 323-372) antibody
LRRTM1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) (AA 179-228) antibodyLRRTM1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Pig, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) (AA 88-117) antibodyLRRTM1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24182 unconjugated
anti-Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) (AA 95-125), (Middle Region) antibodyLRRTM1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7235868)
Blocking Peptide: (ABIN7235868)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))
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别名
- LRRTM1
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背景
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Leucine-rich repeat transmembrane neuronal protein 1,Leucine rich repeat transmembrane neuronal 1 (LRRTM1) is a synaptogenic, cell adhesion protein that contributes to the regulation of synapse density and synaptic transmission. The LRRTM family in mammals includes four postsynaptic proteins, which have been shown to interact with presynaptic neurexins and heparan sulphate proteoglycan glypican on the presynaptic side1. In human and mouse genomes, LRRTM1 is encoded by a single exon and is predominantly expressed in the nervous system. LRRTM1 is a single-membrane-spanning transmembrane protein and its structure contains ten N-terminal LRR repeats, a single pass transmembrane domain, and a cytoplasmic C-terminal tail comprising a PDZ-binding motif1.Mutations in human genes encoding the LRRTM proteins are implicated in cognitive disorders. In particular, LRRTM1 is associated to human handedness and schizophrenia1,2. Studies on Lrrtm1 knockout mice shows deficits in behavioral responses to stressful situations and novel objects, spatial memory and social discrimination deficits3. LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of LRRTM1 in retinothalamic convergence in vision4.
Alternative names: LRRTM1, Leucine-rich repeat transmembrane neuronal protein 1 -
基因ID
- 74342
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NCBI登录号
- NM_178839
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UniProt
- Q8K377
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途径
- Synaptic Membrane
抗原
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