-
- 抗原 See all HCN3 抗体
- HCN3 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3))
-
抗原表位
- AA 727-744, Intracellular
-
适用
- 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This HCN3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to HCN3 Channel
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Human,mouse - identical
- 产品特性
- Anti-HCN3 Antibody (ABIN7043281, ABIN7044972 and ABIN7044973) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize HCN3 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)QRATGDGSPRRKGSGSER corresponding to amino acid residues 727-744 of rat HCN3
- 亚型
- IgG
- Top Product
- Discover our top product HCN3 Primary Antibody
-
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (C-Term) antibody
HCN3 适用: 大鼠, 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (AA 611-660) antibodyHCN3 适用: 大鼠, 人, 小鼠, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (AA 715-728) antibodyVerified HCN3 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (Internal Region) antibodyVerified HCN3 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (AA 190-201), (Extracellular) antibodyHCN3 适用: 大鼠 WB, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50
Application Dilutions Western blot wb: 1:200
- 说明
-
Cited Application: IHC
Negative Control: (ABIN7235790)
Blocking Peptide: (ABIN7235790)
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
- 抗原
- HCN3 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3))
- 别名
- HCN3 (HCN3 产品)
- 背景
-
K+/Na+ Hyperpolarization-activated cyclic nucleotide-gated channel 3, BCNG4, Hac3,Hyperpolarization-activated cation currents (Ih) appear in the heart and brain and play a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1,2The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family (HCN), which comprises of four homologous members, named HCN1-4. Each HCN subunit consist of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain to cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers.2The channels are closely related to each other and share homology of about 60 % . However, they differ from each other in their cytoplasmic N- and the C-terminus. HCN1-4 mainly differ from each other with regard to their speed of activation and the extent by which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4.2,3The HCN3 channels are abundant in the brain where high expression of HCN3 mRNA was found in the hypothalamus.
Alternative names: HCN3, K+/Na+ Hyperpolarization-activated cyclic nucleotide-gated channel 3, BCNG4, Hac3 - 基因ID
- 114245
- NCBI登录号
- NM_020897
- UniProt
- Q9JKA8
-
You are here:
