GRM8 抗体 (Extracellular, N-Term)
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Quick Overview for GRM8 抗体 (Extracellular, N-Term) (ABIN7043256)
抗原
See all GRM8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 365-377, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 8
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse,human - 12,13 amino acid residues identical
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产品特性
- Anti-mGluR8 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR8. Anti-mGluR8 (extracellular) Antibody (ABIN7043256 and ABIN7044363) can be used in western blot and immunohistochemistry applications. It has been designed to recognize mGluR8 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ENFG(S)KLGSHGKR, corresponding to amino acid residues 365-377 of rat mGluR8
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 8 (GRM8) (AA 440-583) antibody
GRM8 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4C1C1 unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (N-Term) antibodyGRM8 适用: 人, 小鼠, 大鼠, 猴, 兔, Bat, 马, 小鸡, 犬, Hamster, 绵羊 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) antibodyGRM8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (AA 486-575) antibodyGRM8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A7 unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (C-Term) antibodyGRM8 适用: 人, 小鼠, 大鼠, 猴, Bat, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (AA 486-575) antibodyGRM8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (AA 841-890) antibodyGRM8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 8 (GRM8) (Extracellular Domain), (N-Term) antibodyGRM8 适用: 人 IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235709)
Blocking Peptide: (ABIN7235709)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
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别名
- GRM8
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背景
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Synonyms: Metabotropic glutamate receptor 8, GRM8, mGlu8, GPRC1H
Description: Metabotropic glutamate receptors (mGluRs), heptahelical transmembrane receptors coupled to G-proteins, contribute to the regulation of neuronal excitability and synaptic transmission1. Genes coding for eight mGluRs (denoted mGluR1-8) with different splice variants have been identified and classified into three groups based on sequence homology, pharmacology, and signaling pathways. Group I mGluRs (mGluR1 and mGluR5) are primarily located postsynaptically. Group II (mGluR2 and mGluR3) are present both postsynaptically and presynaptically outside the release site. Group III mGluRs (mGluR4, mGluR6, mGluR7, and mGluR8) couple to Gαi/o to inhibit adenylyl cyclase found in the presynaptic active zone2.The mGluR8 receptor is detected in the olfactory bulb, thalamus, pontine gray, cerebral cortex, hippocampus, cerebellum, and retina3. Electrophysiological studies suggest that mGluR8 functions as a presynaptic autoreceptor to regulate glutamate release from the lateral perforant path terminals in the mouse dentate gyrus4. It is suggested that mGluR8, like other group III mGluRs, controls glutamate release by inhibiting voltage-gated Ca2+ channels.Targeted deletion of the mGluR8 gene in mice produces subtle behavioral alterations such as reduced habituation to novelty, hyperactivity, context-dependent but not cue-dependent disruption of the freezing response in the fear conditioning test, and increased anxiety5.
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基因ID
- 60590
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NCBI登录号
- NM_000845
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UniProt
- P70579
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途径
- cAMP Metabolic Process, Synaptic Membrane
抗原
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