Metabotropic Glutamate Receptor 3 抗体 (Extracellular)
Quick Overview for Metabotropic Glutamate Receptor 3 抗体 (Extracellular) (ABIN7043248)
抗原
See all Metabotropic Glutamate Receptor 3 (GRM3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 24-38, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 3
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human,monkey - 14,15 amino residues identical
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产品特性
- Anti-mGluR3 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR3. The epitope is specific for mGluR3 and will not cross-react with the closely related mGluR2. Anti-mGluR3 (extracellular) Antibody (ABIN7043248, ABIN7044342 and ABIN7044343) can be used in western blot, live cell imaging and immunohistochemistry applications. It has been designed to recognize mGluR3 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GDHNFMRREIKIEGD, corresponding to amino acids 24-38 of rat mGluR3
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 433-576) antibody
GRM3 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 7A5A6 unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 433-576) antibodyGRM3 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6H10C3 unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (N-Term) antibodyGRM3 适用: 人, Cow, 马, 猴, Pig WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (N-Term) antibodyGRM3 适用: 人, 小鼠, 大鼠, Cow, 马, 猴, Hamster, Pig IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (C-Term) antibodyGRM3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 23-170) antibodyGRM3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 46-354) antibodyGRM3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) antibodyGRM3 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 3 (GRM3) (AA 568-819) antibodyGRM3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:600
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说明
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Cited Application: IFC
Negative Control: (ABIN7235689)
Blocking Peptide: (ABIN7235689)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))
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别名
- GRM3
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背景
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Metabotropic glutamate receptor 3, GRM3, mGlu3, GPRC1C,L-glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/G0 and hence inhibit cAMP formation following receptor activation.1,2mGluR3 is expressed in neurons and glia in many brain regions including the cerebral cortex, hippocampus and brain stem. mGluR3 expression is predominantly presynaptic consistent with its role as an inhibitory autoreceptor, that is, activation of mGluR3 by glutamate inhibits additional glutamate release from the same neurons.1,2Several lines of evidence suggest that mGluR3 is important for long term depression, glial function and neuroprotection. Some studies, though not all, have shown a genetic association of mGluR3 gene polymorphisms with psychosis and with schizophrenia-related phenotypes. Based in these findings, mGluR3 has been suggested as a therapeutic target for both psychosis and schizophrenia.3
Alternative names: mGluR3, Metabotropic glutamate receptor 3, GRM3, mGlu3, GPRC1C -
基因ID
- 24416
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NCBI登录号
- NM_000840
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UniProt
- P31422
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途径
- cAMP Metabolic Process, Synaptic Membrane
抗原
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