GRM2 抗体 (Extracellular)
Quick Overview for GRM2 抗体 (Extracellular) (ABIN7043247)
抗原
See all GRM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 109-121, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 2
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human,dog,monkey - identical
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产品特性
- Anti-mGluR2 (extracellular) Antibody is directed against an epitope of rat mGluR2. The epitope is specific for mGluR2 and will not cross-react with the closely related mGluR3 channel. Anti-mGluR2 (extracellular) Antibody (ABIN7043247, ABIN7044340 and ABIN7044341) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize mGluR2 from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: SLSRGADGSRHIC, corresponding to amino acids 109-121 of rat mGluR2
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibody
GRM2 适用: 人 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 6E4F6 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibodyGRM2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A10B9 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 小鼠, Cow, 犬, 兔, Hamster, Pig, Bat WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 93-221) antibodyGRM2 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 犬, 兔, Hamster, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (Internal Region) antibodyVerified GRM2 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 801-872) antibodyGRM2 适用: 大鼠 ELISA, WB, IF (p), IHC (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 681-715) antibodyGRM2 适用: 人 WB 宿主: 兔 Polyclonal RB57773 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) antibodyGRM2 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Cited Application: IFC
Negative Control: (ABIN7235685)
Blocking Peptide: (ABIN7235685)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))
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别名
- GRM2
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背景
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Metabotropic glutamate receptor 2, GRM2, mGlu2, GPRC1B,L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation.1,2mGluR2 is widely distributed throughout the brain with high expression in several limbic areas including the cortex, hippocampus and amygdala. mGluR2 is localized primarily presynaptically, although postsynaptic localization has also been described.In line with its presynaptic localization, mGluR2 is thought to function as an autoreceptor in a negative feedback mechanism that suppress further release of glutamate from the cell on which it is expressed.The involvement of mGluR2 in neuronal excitability and synaptic transmission suggests that modulation of this receptor is a promising strategy for the treatment of neurological and neuropsychiatric disorders such as anxiety, schizophrenia, and pain.3
Alternative names: mGluR2, Metabotropic glutamate receptor 2, GRM2, mGlu2, GPRC1B -
基因ID
- 24415
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NCBI登录号
- NM_000839
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UniProt
- P31421
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途径
- cAMP Metabolic Process, Dicarboxylic Acid Transport
抗原
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