GJC1 抗体 (Intracellular)
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Quick Overview for GJC1 抗体 (Intracellular) (ABIN7043207)
抗原
See all GJC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 153-166, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Connexin-45
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Connexin-45 (GJC1) Antibody is directed against an epitope of rat Connexin-45. Anti-Connexin-45 (GJC1) Antibody (ABIN7043207, ABIN7044085 and ABIN7044086) can be used in western blot and immunohistochemistry applications. It has been designed to recognize Cx45 from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KEQSQPKPKHDGRR, corresponding to amino acid residues 153-166 of rat Connexin-45
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亚型
- IgG
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anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 91-131), (N-Term) antibody
GJC1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 247-396) antibodyGJC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 91-131) antibodyGJC1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 81-130) antibodyGJC1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 297-396) antibodyGJC1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (AA 354-367) antibodyGJC1 适用: 人, 大鼠, 小鼠, 犬 WB, IHC, IHC (p), ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) antibodyGJC1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (N-Term) antibodyGJC1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (C-Term) antibodyGJC1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 1, 45kDa (GJC1) (C-Term) antibodyGJC1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP
Negative Control: (ABIN7235558)
Blocking Peptide: (ABIN7235558)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GJC1 (Gap Junction Protein, gamma 1, 45kDa (GJC1))
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别名
- GJC1
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背景
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Synonyms: CX45, Gap junction γ1 protein, Gap junction α7 protein, GJA7
Description: Gap junctions are plasma membrane domains of intercellular channels that allow direct connection between the cytoplasm of adjacent cells. They allow exchange of low molecular weight metabolites, ions and small hydrophilic molecules. These channels are formed by head-to-head docking of hexameric hemichannels called connexons, whose subunit proteins are encoded by the connexin (Cx) gene family1-3.The connexin subunit is formed of four-transmembrane spanning domains, harboring two extracellular loops, one cytoplasmic loop and cytoplasmic N- and C-terminal regions. To date, the family of connexin comprises 21 genes in the human genome4.Connexin 45 (Cx45), encoded by the GJC1 gene, is expressed in cardiomyocytes and in developing vasculature in both endothelial and smooth muscle cells4,5.In the heart, Cx45 along with Cx40 and Cx43, play a crucial role in normal electrical conduction and synchronous heart muscle contraction and important for the normal embryonic development of the heart6. Indeed Cx45 forms low conductance and voltage-sensitive gap junctions between the ventricular cardiac myocytes and the core conduction system2. Studies have showed that cardiac connexin Cx45 is upregulated in human failing hearts and has an important role in the regulation of endothelial-induced mural cell differentiation4,5.
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基因ID
- 266706
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NCBI登录号
- NM_005497
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UniProt
- A4GG66
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途径
- Cell-Cell Junction Organization
抗原
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