GABARAP 抗体 (Intracellular, N-Term)
Our Local Distributor
北京 101111
Quick Overview for GABARAP 抗体 (Intracellular, N-Term) (ABIN7043179)
抗原
See all GABARAP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 2-15, Intracellular, N-Term
-
原理
- A Rabbit Polyclonal Antibody to GABA Receptor Associated Protein
-
交叉反应
- 人, 小鼠, 大鼠
-
交叉反应 （详细）
- Due to high homology with GABA receptor associated protein-like proteins the antibody will recognize:GABA receptor associated protein-like 1 (11/14 amino acid residues identical), (Accession Q0VGK0).GABA receptor associated protein-like 3 (11/14 amino acid residues identical), (Accession Q9BY60).May recognize GABA receptor associated protein-like 2 (8/14 amino acid residues identical), (Accession P60522).
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-GABARAP Antibody (ABIN7043179, ABIN7044532 and ABIN7044533) is a highly specific antibody directed against an extracellular epitope of the rat GABA receptor associated protein. The antibody can be used in western blot analysis. It has been designed to recognize GABARAP from human, mouse and rat samples. Due to high homology with GABA receptor associated protein-like proteins the antibody will recognize GABA receptor associated protein 1 and 3 and may recognize GABA receptor associated protein 2.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)KFVYKEEHPFEKRR, corresponding to amino acid residues 2-15 of rat GABARAP
-
亚型
- IgG
-
-
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-100) antibody
GABARAP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30) antibodyGABARAP 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11846 unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibodyGABARAP 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-31), (N-Term) antibodyGABARAP 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30) antibodyGABARAP 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (APC)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal APC
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (Biotin)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (FITC)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal FITC
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (Atto 488)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (Atto 390)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 390
-
-
应用备注
-
WB: 1:800
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235469)
Blocking Peptide: (ABIN7235469)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))
-
别名
- GABARAP
-
背景
-
Synonyms: GABA receptor associated protein, GABARAPL
Description: GABA(A) receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABA associated protein (GABARAP) family interacts specifically with the γ1, γ2S and γ2L subunits of the GABA(A) receptor. GABARAP is expressed in a variety of tissues including heart, brain, placenta, liver and others. The genetic sequence encoding GABARAP is similar to microtubule-associated proteins 1A and 1B1.GABARAP has an asymmetric structure with a basic N-terminal region and an acidic C terminus. GABARAP has a compact fold consisting of four or five-stranded β-sheets with two α-helices on each side. The outer strands of the β-sheets are aligned anti-parallel to the inner strands and helices α3 and α4 are located on one side of the sheet. The presence of α1 and α2 is a unique feature of GABARAP and forms a hydrophilic patch suitable for protein-protein interface. GABARAP exists in a monomeric conformation at low protein concentration and a head-to-tail oligomeric conformation in high salt conditions.GABARAP is involved in intracellular trafficking and is an integral part of the intra-Golgi transport machinery. Thus it is detected in cellular compartments such as the Golgi apparatus and endoplasmic reticulum. GABARAP affects GABA(A) receptors' cell surface expression by increasing their intracellular trafficking. Disruption of cellular microtubules prevents the clustering of both GABARAP and GABA(A) receptors. GABARAP also interacts with other receptors such as the glycine receptor at the postsynaptic site2.
-
基因ID
- 58974
-
NCBI登录号
- NM_007278
-
UniProt
- P60517
-
途径
- Autophagy
抗原
-
