FZD3 抗体 (Intracellular)
Quick Overview for FZD3 抗体 (Intracellular) (ABIN7043142)
抗原
See all FZD3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 581-596, Intracellular
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原理
- A Rabbit Polyclonal antibody to Frizzled-3 receptor.
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特异性
- Intracellular, C-terminus.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human,rat - identical
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产品特性
- A rabbit polyclonal antibody to Frizzled-3 receptor.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: Peptide (C)KVSSYHGSLHRSRDGR, corresponding to amino acid residues 581 - 596 of mouse Frizzled-3
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亚型
- IgG
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anti-Frizzled Family Receptor 3 (FZD3) (AA 121-220) antibody
FZD3 适用: 人, 小鼠, 大鼠, 非洲爪蟾 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (AA 23-205) antibodyFZD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (N-Term) antibodyFZD3 适用: 人, 小鼠, 大鼠, Bat, Cow, 犬, Hamster, 马, 猴, Pig, 兔, 小鸡 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (AA 55-157) antibodyFZD3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (AA 55-157) antibodyFZD3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B8 unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (Internal Region) antibodyFZD3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (Internal Region) antibodyFZD3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (AA 55-157) antibodyFZD3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (AA 481-530) antibodyFZD3 适用: 人, 小鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 3 (FZD3) (Internal Region) antibodyFZD3 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235344)
Blocking Peptide: (ABIN7235344)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- FZD3 (Frizzled Family Receptor 3 (FZD3))
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别名
- FZD3
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背景
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Frizzled Class Receptor 3, Fz-3,Frizzled 3, encoded by FZD3 gene, is a receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes 1. It belongs to the Frizzled protein family that contains multiple hydrophobic domains predicted to form seven transmembrane helices, similar to G protein coupled receptors. Conserved sequences are found in the Frizzled proteins extracellular cysteine-rich domain (CRD), the putative transmembrane domains, parts of the intracellular loops and a juxtamembrane motif, KTXXXW, found in the membrane-proximal C-terminal region of all Frizzleds. The C-terminal tails, however, are highly divergent 2. Frizzled-3 is constitutively expressed in murine melanocyte precursors, melanocytes and human melanocytes 3, it is also expressed in the epidermis of the developing embryo 4 and its expression levels are changing between different parts of the ovary throughout the process of embryogenesis 1. Because of its crucial role in regulating proper embryogenesis and its role in the development of the central nervous system, including synaptogenesis and structural plasticity, mutations in FZD3 gene were shown to have a significant association with the development of schizophrenia and other psychotic disorders 5.
Alternative names: Frizzled Class Receptor 3, Fz-3 -
基因ID
- 14365
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NCBI登录号
- NM_145866
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UniProt
- Q61086
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途径
- WNT signaling, Tube Formation
抗原
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