EPH Receptor B4 抗体 (Extracellular, N-Term)
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Quick Overview for EPH Receptor B4 抗体 (Extracellular, N-Term) (ABIN7043127)
抗原
See all EPH Receptor B4 (EPHB4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 472-486, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to EphB4 Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-EphB4 (extracellular) Antibody (ABIN7043127, ABIN7044253 and ABIN7044254) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry, and live cell flow cytometry applications. It has been designed to recognize EphB4 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HEKGAEGPSSVRFLK, corresponding to amino acid residues 472-486 of mouse EphB4
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亚型
- IgG
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anti-EPH Receptor B4 (EPHB4) (AA 300-540) antibody
EPHB4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B4 (EPHB4) antibodyEPHB4 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 5B8F7 unconjugated
anti-EPH Receptor B4 (EPHB4) antibodyEPHB4 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-EPH Receptor B4 (EPHB4) antibodyEPHB4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14731 unconjugated
anti-EPH Receptor B4 (EPHB4) (AA 198-323) antibodyEPHB4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G11 unconjugated
anti-EPH Receptor B4 (EPHB4) (AA 562-612) antibodyEPHB4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7H4A6 unconjugated
anti-EPH Receptor B4 (EPHB4) (AA 889-923), (C-Term) antibodyEPHB4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50408 unconjugated
anti-EPH Receptor B4 (EPHB4) (AA 198-323) antibodyEPHB4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D1 unconjugated
anti-EPH Receptor B4 (EPHB4) (C-Term) antibodyEPHB4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235298)
Blocking Peptide: (ABIN7235298)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EPH Receptor B4 (EPHB4)
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别名
- EPHB4
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背景
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Synonyms: Ephrin type-B receptor 4, Eph receptor B4, Hepatoma transmembrane kinase, HTK
Description: EphB4 (Ephrin type-B receptor 4) is a member of the Eph family of receptor tyrosine kinases. Signaling pathways of these receptors play important roles in regulating numerous physiological processes during development including cell morphology, proliferation, migration and axonal guidance, dendritic spine formation and neural plasticity. Ephrins transduce bidirectional signals based on their distribution on the communicating cell surfaces. Eph receptors mediate forward signaling in one cell while ephrin ligands transmit reverse signaling in an adjacent cell1,2.Eph receptors consist of two large subfamilies: EphAs and EphBs that bind to either glycophosphatidylinositol (GPI)-anchored ephrin-A ligands or transmembrane ephrin-B ligands respectively. Each eph receptor may interact with multiple ligands, except for EPHB4, which only binds ephrin-B22.EPHB4 is expressed primarily during embryonic development in neural tissue and immature vasculature. Studies show that EphB4 is implicated in the growth of several epithelial tumors and is a promising target in cancer therapy. EphB4 signaling was found to promote tumor growth, invasiveness, chemoresistance and tumor angiogenesis3.
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基因ID
- 13846
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NCBI登录号
- NM_004444
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UniProt
- P54761
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途径
- RTK signaling
抗原
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