EPH Receptor B1 抗体 (Extracellular, N-Term)
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Quick Overview for EPH Receptor B1 抗体 (Extracellular, N-Term) (ABIN7043126)
抗原
See all EPH Receptor B1 (EPHB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 485-497, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to EphB1 Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-EphB1 (extracellular) Antibody is directed against an extracellular epitope of mouse EphB1. Anti-EphB1 (extracellular) Antibody (ABIN7043126, ABIN7044251 and ABIN7044252) can be used in western blot, immunocytochemistry and indirect flow cytometry applications. The antibody is suitable for live cell imaging. It has been designed to recognize EphB1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSQTNTARIDGLR, corresponding to amino acid residues 485-497 of mouse EphB1
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亚型
- IgG
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anti-EPH Receptor B1 (EPHB1) (AA 955-984), (C-Term) antibody
EPHB1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1648 unconjugated
anti-EPH Receptor B1 (EPHB1) antibodyKD Validated EPHB1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5335 unconjugated Recombinant Antibody
anti-EPH Receptor B1 (EPHB1) (AA 221-320) antibodyEPHB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 56-88), (N-Term) antibodyEPHB1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 374-409) antibodyEPHB1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50839 unconjugated
anti-EPH Receptor B1 (EPHB1) (pTyr594), (pTyr604) antibodyEPHB1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) antibodyEPHB1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (pTyr928) antibodyEPHB1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor B1 (EPHB1) (AA 304-339) antibodyEPHB1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50839 unconjugated
anti-EPH Receptor B1 (EPHB1) (C-Term) antibodyEPHB1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:800
FC: 1:15
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235294)
Blocking Peptide: (ABIN7235294)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EPH Receptor B1 (EPHB1)
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别名
- EPHB1
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背景
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Synonyms: Ephrin type-B receptor 1, Eph receptor B1, Tyrosine-protein kinase receptor EPH-2
Description: Eph receptors are the largest family of receptor tyrosine kinases (RTKs). EphA receptors (EphA1-10) bind ephrinA ligands which are GPI-linked proteins and EphB receptors (EphB1-6) bind ephrinB ligands which are membrane protein with one transmembrane domain1,2. Within each subfamily, interactions between receptor and ligand are promiscuous. In addition, Eph receptors can also bind ephrins from the other class2. Forward and reverse signaling through Eph receptors is a unique characteristic to this RTK since ephrins are physically linked to the plasma membrane3.Structurally, Eph receptors contain an extracellular ligand-binding domain, a transmembrane domain and an intracellular C-terminal domain responsible for intracellular signaling1. Forward Eph receptor signaling involves autophosphorylation of the receptor via a tyrosine kinase domain, as well as phosphorylation of other proteins. Known effectors of the forward signaling include Src kinase and Ras/Rho GTPases2. Much less is known about the reverse signaling mediated by Eph receptors. Besides from acting independently, Eph receptors can also signal in concert with other receptors. For example, Eph receptors cooperate with FGF receptor, NMDA ligand-gated ion channel and chemokine G-protein coupled receptor2.Biological activities attributed to the Eph receptor-ephrin signaling module include establishing neuronal connections, mediating neuronal plasticity and repair following neuronal injury2,4. Eph receptors may also have a role in the immune system5.Eph receptors are expressed in the developing nervous system, and in the adult brain. It is also detected in the pancreas, intestine, bone and lymphocytes. In cancer cells, Eph receptors and ephrins are overexpressed2,6,7. They are also implicated in neurodegenerative disorders like Alzheimer's disease1.
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基因ID
- 270190
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NCBI登录号
- NM_004441
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UniProt
- Q8CBF3
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途径
- RTK signaling
抗原
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