EPH Receptor A6 抗体 (Extracellular)
Quick Overview for EPH Receptor A6 抗体 (Extracellular) (ABIN7043125)
抗原
See all EPH Receptor A6 (Epha6) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 482-495, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to EphA6 Receptor
-
特异性
- Extracellular, N-terminus
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-EphA6 (extracellular) Antibody (ABIN7043125, ABIN7044247 and ABIN7044248) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize EphA6 from rat, mouse, and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)KEHEQLTYSSTRSK, corresponding to amino acid residues 482-495 of rat EphA6
-
亚型
- IgG
-
-
anti-EPH Receptor A6 (Epha6) antibody
Epha6 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) (AA 132-279) antibodyEpha6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) antibodyEpha6 适用: 人, 小鼠, 大鼠 ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) (AA 695-795) antibodyEpha6 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3D5B10 unconjugated
anti-EPH Receptor A6 (Epha6) (AA 1006-1035), (C-Term) antibodyEpha6 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1637-1638 unconjugated
anti-EPH Receptor A6 (Epha6) (C-Term) antibodyEpha6 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) (C-Term) antibodyEpha6 适用: 人, 小鼠, 大鼠 IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) antibodyEpha6 适用: 人 WB 宿主: 小鼠 Monoclonal 6C9 unconjugated
anti-EPH Receptor A6 (Epha6) (AA 1-1036) antibodyEpha6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-EPH Receptor A6 (Epha6) (AA 613-712) antibodyEpha6 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2H2 unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:400
-
说明
-
Negative Control: (ABIN7235290)
Blocking Peptide: (ABIN7235290)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- EPH Receptor A6 (Epha6)
-
别名
- EPHA6
-
背景
-
Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2,EphA6 is an erythropoietin-producing hepatocellular (Eph) receptor that belongs to the tyrosine kinase receptor family. The Eph receptor family consists of 9 EphA receptors and 5 EphB receptors, which serve key roles in normal physiology, including cell migration, cell adhesion, cell proliferation and neuronal synaptic plasticity. These activities depend on the binding of their Eph receptor-interacting (ephrin) proteins, of which include 8 members. Compelling data has demonstrated that Eph receptors and ephrins affect tumor growth, invasiveness, angiogenesis and metastasis1. They are also involved in brain development, learning and memory2.EphA6 signaling pathways are inhibitory for developing axons and blocking these pathways enhances regeneration following spinal cord and brain injury, rendering EphA6 an appealing drug target3.Eph receptors contain an extracellular structure consisting of an ephrin binding domain, the juxtamembrane region connects the extracellular portion of the receptor to the intracellular kinase domain. Two Tyrosine residues on the juxtamembrane region mediate autophosphorylation and receptor dimerization mediates the formation of heterocomplexes that are required for signaling4.
Alternative names: Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2 -
基因ID
- 29202
-
NCBI登录号
- NM_001080448
-
UniProt
- P54758
-
途径
- RTK signaling
抗原
-
