DRD5 抗体 (Extracellular)
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- 抗原 See all DRD5 抗体
- DRD5 (Dopamine Receptor D5 (DRD5))
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抗原表位
- AA 199-211, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DRD5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to D5 Dopamine Receptor
- 特异性
- 2nd extracellular loop
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 （详细）
- Unlikely to recognize human samples.
- 预测反应
- Mouse - 12,13 amino acid residues identical
- 产品特性
- Anti-D5 Dopamine Receptor (extracellular) Antibody is directed against an epitope located at the 2nd extracellular loop of the rat D5 dopamine receptor. Anti-D5 Dopamine Receptor (extracellular) Antibody (ABIN7043111, ABIN7044234 and ABIN7044235) can be used in western blot analysis and immunohistochemical applications, and recognizes DRD5 from rat and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat DRD5
- 亚型
- IgG
- Top Product
- Discover our top product DRD5 Primary Antibody
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anti-Dopamine Receptor D5 (DRD5) (AA 361-477) antibody
DRD5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Internal Region) antibodyVerified DRD5 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 323-477) antibodyDRD5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 251-350) antibodyDRD5 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 421-456), (C-Term) antibodyDRD5 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB52763 unconjugated
anti-Dopamine Receptor D5 (DRD5) (Extracellular Domain) antibodyDRD5 适用: 人, 大鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Cytoplasmic Domain) antibodyDRD5 适用: 人, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (N-Term) antibodyDRD5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 19-56), (N-Term) antibodyDRD5 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52770 unconjugated
anti-Dopamine Receptor D5 (DRD5) antibodyDRD5 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7235250)
Blocking Peptide: (ABIN7235250)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- DRD5 (Dopamine Receptor D5 (DRD5))
- 别名
- DRD5 (DRD5 产品)
- 背景
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DRD5, D(1B) dopamine receptor,The D5 dopamine receptor (D5 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1 The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D5 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex, hippocampus and striatum. In the periphery, the D5 receptor has been localized in the adrenal cortex, kidney and intestinal tract.The exact physiological function of the D5 receptor subtype remains poorly understood. Studies with D5 receptor knockout mice have shown no overt alterations in locomotor or cognitive functions. However, knockout mice do develop severe hypertension suggesting a role of the D5 receptor in the modulation of neuronal pathways regulating blood pressure responses.2,3
Alternative names: D5 Dopamine Receptor, DRD5, D(1B) dopamine receptor - 基因ID
- 25195
- NCBI登录号
- NM_000798
- UniProt
- P25115
- 途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
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