DRD3 抗体 (Extracellular)
Quick Overview for DRD3 抗体 (Extracellular) (ABIN7043109)
抗原
See all DRD3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 15-29, Extracellular
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原理
- A Rabbit Polyclonal Antibody to D3 Dopamine Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,15 amino acid residues identical
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产品特性
- Anti-D3 Dopamine Receptor (extracellular) Antibody is directed against an epitope located at the extracellular N-terminus of the rat D3 dopamine receptor. Anti-D3 Dopamine Receptor (extracellular) Antibody (ABIN7043109, ABIN7044231 and ABIN7044232) can be used in western blot analysis and immunohistochemical applications, and recognizes DRD3 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CGAENSTGVNRARPH, corresponding to amino acid residues 15-29 of rat DRD3
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亚型
- IgG
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anti-Dopamine Receptor D3 (DRD3) (AA 352-446) antibody
DRD3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 213-329) antibodyDRD3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 213-329) antibodyDRD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (Cytoplasmic Domain) antibodyDRD3 适用: 人, 小鼠, 犬, 马, Pig, 猴, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (C-Term) antibodyDRD3 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 352-446) antibody (AbBy Fluor® 594)DRD3 适用: 人, 大鼠, 小鼠 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 594
anti-Dopamine Receptor D3 (DRD3) (AA 213-329) antibodyDRD3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) antibodyDRD3 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 5B10 unconjugated Recombinant Antibody
anti-Dopamine Receptor D3 (DRD3) (Internal Region) antibodyDRD3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D3 (DRD3) (AA 270-319) antibodyDRD3 适用: 人, 犬, 马, Pig, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC|IFC
Negative Control: (ABIN7235243)
Blocking Peptide: (ABIN7235243)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- DRD3 (Dopamine Receptor D3 (DRD3))
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别名
- DRD3
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背景
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DRD3,The D3 Dopamine Receptor (D3 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D3 receptor distribution in the brain is relatively restricted to limbic areas such as striatum, islands of Calleja and olfactory tubercle. In the periphery, it is expressed in the kidney particularly in proximal tubules.1The exact physiological function of the D3 receptor remains to be fully elucidated. In studies using D3 receptor knockout mice, the most prominent dysfunction was the development of rennin-dependent hypertension. Potential roles in reinforcement and reward behaviors have also been suggested as well as roles in neuropsychiatric disorders such as drug abuse and schizophrenia.2
Alternative names: D3 Dopamine Receptor, DRD3 -
基因ID
- 29238
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NCBI登录号
- NM_000796
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UniProt
- P19020
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity
抗原
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