DPP10 抗体 (C-Term, Extracellular)
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Quick Overview for DPP10 抗体 (C-Term, Extracellular) (ABIN7043099)
抗原
See all DPP10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 356-370, C-Term, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 10
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- 15 amino acid residues identical,Mouse - 14, human - 12
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产品特性
- Anti-DPP10 (extracellular) Antibody (ABIN7043099, ABIN7045044 and ABIN7045045) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize DPP10 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CSRKYEMTSDTWISK, corresponding to amino acid residues 356-370 of rat DPP10
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亚型
- IgG
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anti-Dipeptidylpeptidase 10 (DPP10) (Internal Region) antibody
Verified DPP10 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Dipeptidylpeptidase 10 (DPP10) (Internal Region) antibodyDPP10 适用: 人, 马, Cow, 犬, 猴, 豚鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidylpeptidase 10 (DPP10) (AA 150-177) antibodyDPP10 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB23704 unconjugated
anti-Dipeptidylpeptidase 10 (DPP10) (Extracellular Domain) antibodyDPP10 适用: 人, 马, Cow, 犬, 猴, Pig, 兔, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidylpeptidase 10 (DPP10) (C-Term) antibodyDPP10 适用: 人, 马, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidylpeptidase 10 (DPP10) (AA 150-177) antibodyDPP10 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP
Negative Control: (ABIN7235212)
Blocking Peptide: (ABIN7235212)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- DPP10 (Dipeptidylpeptidase 10 (DPP10))
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别名
- DPP10
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背景
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Synonyms: Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase X, DPP X, DPPY, DPL2, DPRP3
Description: Dipeptidyl peptidase 10 (DPP10, DPPY) is a member of the prolyl oligopeptidase family (shares a 30 % sequence identity with DPP4) and belongs to the S9B serine protease subfamily. DPP10 is a homologous glycosylated, single-pass type II transmembrane protein that lacks the crucial serine residue of the catalytic triad. Unlike other KV4 subunits such as DPP6, DPP10 has a restricted expression pattern including the brain, adrenal gland and pancreas. The presence of DPP10 in endocrine cells suggests that the protein may also have an additional function related to the regulation of hormone secretion. DPP10 accelerates the activation and inactivation of KV4.3 channel gating with distinct biophysical properties.DPP10 associates with the α-subunits of the KV4 subfamily to form a ternary complex of approximately 750 kDa1. In addition, DPP10 forms complexes with other auxiliary subunits of the KV4 channels. In dorsal root ganglion DPP10 is co-localized with K+ channel-interacting proteins 1 and 2 (KChIPs) in the somatic surface and cytoplasm of KV4.3 nociceptors. Recently it has been hypothesized that KV4/KChIP/DPPL ternary complexes exist in subthreshold A-type K+ currents (Isas) expressing nociceptors and pain-modulating spinal interneurons2.DPP10 has been implicated in various pathologies. Aggregation of the protein is associated with neurodegenerative conditions such as Alzheimer's, diffuse Lewy body disease and fronto-temporal dementia3.
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基因ID
- 363972
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NCBI登录号
- NM_020868
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UniProt
- Q6Q629
抗原
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