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- 抗原 See all DPP6 抗体
- DPP6 (Dipeptidyl-Peptidase 6 (DPP6))
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抗原表位
- AA 414-426, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DPP6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 6
- 特异性
- Extracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse - identical
- 产品特性
- Anti-DPP6 (extracellular) Antibody (ABIN7043098, ABIN7045042 and ABIN7045043)) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize DPP6 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KKHEDESEAWLHR, corresponding to amino acid residues 414-426 of human DPP6
- 亚型
- IgG
- Top Product
- Discover our top product DPP6 Primary Antibody
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anti-Dipeptidyl-Peptidase 6 (DPP6) (AA 667-865) antibody
DPP6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (Extracellular Domain) antibodyDPP6 适用: 人, 小鼠, 大鼠, Cow, 兔, 马, 猴, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (Middle Region) antibodyDPP6 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (AA 720-769) antibodyDPP6 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 斑马鱼, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (AA 252-301) antibodyDPP6 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (AA 117-210) antibodyDPP6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dipeptidyl-Peptidase 6 (DPP6) (Middle Region) antibodyDPP6 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 豚鼠, 斑马鱼, Pig WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200-1:500
- 说明
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Negative Control: BLP-PC146
Blocking Peptide: BLP-PC146
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- DPP6 (Dipeptidyl-Peptidase 6 (DPP6))
- 别名
- DPP6 (DPP6 产品)
- 背景
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Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2,Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary glycoproteinic subunit of voltage-dependent K+ channel 4 (KV4.x), that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2.DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV - the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1,3.Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4.DPP6 proteins are widely expressed throughout both of the nervous systems - albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5.Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5,6. Endometriosis - a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population - has been linked with DPP6 in genome wide associations studies (GWASs)7.
Alternative names: DPP6, Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2 - 基因ID
- 1804
- NCBI登录号
- NM_130797
- UniProt
- P42658
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