CCKBR 抗体 (Extracellular)
Quick Overview for CCKBR 抗体 (Extracellular) (ABIN7043059)
抗原
See all CCKBR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-53, Extracellular
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原理
- A Rabbit Polyclonal Antibody to the Cholecystokinin B Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- human - 13,Rat - 14,15 amino acid residues identical
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产品特性
- Anti-CCKBR (extracellular) Antibody (ABIN7043059, ABIN7044183 and ABIN7044184) is a highly specific antibody directed against an epitope of the mouse cholecystokinin B receptor. The antibody can be used in western blot, indirect flow cytometry, and immunohistochemistry applications. It has been designed to recognize CCKBR from mouse, rat, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor
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亚型
- IgG
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anti-Cholecystokinin B Receptor (CCKBR) (Internal Region) antibody
Verified CCKBR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 301-400) antibodyCCKBR 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 243-333) antibodyCCKBR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (C-Term) antibodyCCKBR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Extracellular Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Cytoplasmic Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) antibodyCCKBR 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 277-326) antibodyCCKBR 适用: 人, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100-1:200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IFC
Negative Control: (ABIN7235114)
Blocking Peptide: (ABIN7235114)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CCKBR (Cholecystokinin B Receptor (CCKBR))
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别名
- CCKBR
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背景
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Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR,Cholecystokinin B receptor (CCKBR), also known as the Gastrin receptor and CCKR2, belongs to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.
Alternative names: CCKBR, Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR -
基因ID
- 12426
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NCBI登录号
- NM_176875
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UniProt
- P56481
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途径
- Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour
抗原
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