CCR9 抗体 (2nd Extracellular Loop)
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Quick Overview for CCR9 抗体 (2nd Extracellular Loop) (ABIN7043036)
抗原
See all CCR9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 205-218
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原理
- A Rabbit Polyclonal Antibody to CCR9 Chemokine Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 10,14 amino acid residues identical
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产品特性
- Anti-CCR9 (extracellular) Antibody (ABIN7043036, ABIN7044177 and ABIN7044178) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect live cell flow cytometry applications. It has been designed to recognize CCR9 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DESTKLKSAVLTLK, corresponding to amino acid residues 205-218 of human CCR9
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 9 (CCR9) antibody
CCR9 适用: 人 WB, ELISA, IF, IP 宿主: 兔 Monoclonal 4G2 unconjugated Recombinant Antibody
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) antibodyCCR9 适用: 人 FACS 宿主: 小鼠 Monoclonal C9Mab-1 unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (AA 3-22), (N-Term) antibodyCCR9 适用: 人, 小鼠 FACS, IF, ICC, IHC (fro) 宿主: 大鼠 Monoclonal 7E7 unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) antibodyCCR9 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (C-Term) antibodyCCR9 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (AA 65-160) antibodyCCR9 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (N-Term) antibodyCCR9 适用: 小鼠 FACS, Neut 宿主: 兔 Chimeric 9B1 unconjugated Recombinant Antibody
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (AA 1-369) antibodyCCR9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) (Extracellular Domain) antibodyCCR9 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 9 (CCR9) antibodyCCR9 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235059)
Blocking Peptide: (ABIN7235059)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CCR9 (Chemokine (C-C Motif) Receptor 9 (CCR9))
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别名
- CCR9
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背景
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Synonyms: C-C chemokine receptor type 9, CC-CKR-9, G-protein coupled receptor 28, GPR28, GPR-9-6, CDw199
Description: CCR9 (C-C chemokine receptor type 9) belongs to the β-chemokine receptor family of the G-protein coupled receptor superfamily. Chemokine receptors play a crucial role in cell migration and are considered to be important therapeutic targets for inflammatory diseases and in tumor chemoresistance and metastasis. In addition, high expression of CCR9 has been reported in a wide range of cancers including melanoma, ovarian cancer, lung cancer, breast cancer and colon cancer. Thus, CCR9 is considered to be a potential tumor biomarker in diagnosis and therapy of cancer1,2. Under physiological conditions, CCR9 is mainly expressed in immature T lymphocytes and on the surface of intestinal cells2.CCR9 receptor interacts with its specific ligand- chemokine ligand 25 (CCL25, thymus-expressed chemokine) in a two-step binding mechanism in which the C-terminal region of CCL25 first binds the N-terminus region and extracellular loops of the receptor followed by the binding of the N-terminus of the chemokine. The two-step biding mechanism stabilizes the receptor in an active conformation that facilitates intracellular signaling1.
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基因ID
- 10803
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NCBI登录号
- NM_001256369
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UniProt
- P51686
抗原
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