CCR5 抗体 (Extracellular)
Quick Overview for CCR5 抗体 (Extracellular) (ABIN7043034)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 178-192, Extracellular
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原理
- A Rabbit Polyclonal Antibody to CCR5 Chemokine Receptor
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特异性
- 2nd extracellular loop
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交叉反应 （详细）
- Not recommended for use with rat and mouse samples.
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预测反应
- Human only
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产品特性
- Anti-Human CCR5 (extracellular) Antibody (ABIN7043034, ABIN7044174 and ABIN7044175) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize CCR5 from human samples only. The antibody is unlikely to recognize the receptor from mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CSSHFPYSQYQFWKN, corresponding to amino acid residues 178-192 of human CCR5
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibody
CCR5 适用: 人 IHC (fro) 宿主: 小鼠 Monoclonal 12D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibodyCCR5 适用: 人, 大鼠 WB, ELISA, FACS, IHC 宿主: 小鼠 Monoclonal 6G11D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 19-34), (N-Term) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 201-300) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 151-200) antibodyCCR5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-22) antibodyCCR5 适用: 人 WB, ELISA, FACS, IP, ICC 宿主: 小鼠 Monoclonal T21-8 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (pSer336) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 100-200) antibodyCCR5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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别名
- CCR5
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背景
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C-C chemokine receptor type 5, C-C CKR-5, CHEMR13, HIV-1 fusion coreceptor, CD195,CCR5 protein is a G-protein coupled receptor (GPCR) responsible for regulating host immune responses and functions against pathogens. The protein plays a key role in transferring immune cells to inflammatory sites and injury. CCR5 is also considered to be an anchor protein for R5-tropic strains of HIV-1 (Human Immunodeficiency Virus-1) to infect immune cells. Thus, CCR5 contributes to the development of AIDS (Acquired Immunodeficiency Syndrome).The receptor is widely expressed in a variety of immune cells involved in the inflammatory responses such as macrophages, monocytes, T cells and dendritic cells1,2.CCR5 is the receptor for the CC ligand 3 (CCL3), CC ligand 4 (CCL4), and CC ligand 5 (CCL5) chemokine ligands. CCR5 and its ligands are upregulated during HIV infection.Studies have shown that lack of homozygosity of CCR5Δ32 variant, a 32 base-pair deletion of the CCR5's gene coding region, is associated with preventing the risk of HIV-1 infection2,3.
Alternative names: CCR5, C-C chemokine receptor type 5, C-C CKR-5, CHEMR13, HIV-1 fusion coreceptor, CD195 -
基因ID
- 1234
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NCBI登录号
- NM_000579
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UniProt
- P51681
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
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