CCR3 抗体 (2nd Extracellular Loop)
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Quick Overview for CCR3 抗体 (2nd Extracellular Loop) (ABIN7043033)
抗原
See all CCR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 183-197
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原理
- A Rabbit Polyclonal Antibody to CCR3 Chemokine Receptor
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交叉反应 （详细）
- Not recommended for use with rat and mouse samples.
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预测反应
- Human only
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产品特性
- Anti-Human CCR3 (extracellular) Antibody (ABIN7043033, ABIN7044172 and ABIN7044173) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect flow cytometry applications. It has been designed to recognize CCR3 from human samples only. The antibody will not recognize the receptor from mouse or rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CSALYPEDTVYSWRH, corresponding to amino acid residues 183-197 of human CCR3
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 3 (CCR3) antibody
CCR3 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8E9H10 unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (C-Term) antibodyCCR3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (C-Term) antibodyCCR3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (AA 306-355) antibodyCCR3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) antibody (PE)CCR3 适用: 人 FACS 宿主: 小鼠 Monoclonal 5E8 PE
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (AA 251-355) antibodyCCR3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) antibodyCCR3 适用: 人 FACS, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (AA 5-28) antibodyCCR3 适用: 人, 小鼠 WB, IHC, IHC (p), ICC 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (Extracellular Domain) antibodyCCR3 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 3 (CCR3) (C-Term) antibodyCCR3 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))
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别名
- CCR3
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背景
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Synonyms: C-C chemokine receptor type 3, Eosinophil eotaxin receptor, CKR3, C-C CKR-3, CMKBR3, B-chemokine receptor, CD193 antigen
Description: CCR3 (C-C chemokine receptor type 3) is a seven transmembrane G-protein coupled receptor (GPCR) that acts as a key regulator in the homeostasis of the immune system. The receptor is responsible for recruiting eosinophils to local inflammatory tissues.CCR3 is the endogenous receptor for Eotaxin, C-C motif chemokine 11 (CCL11). The binding between CCR3 and CCL11 activates G-protein-dependent signaling pathways and thus enables the release of eosinophils progenitor cells and mature eosinophils to the affected tissue. Studies have shown that deficiency in CCR3 protein may reduce the binding of Eotaxin and inhibition of phosphatidylinositol-3-kinase (PI3K) signaling pathway activation and the inactivation of its subunit PI3Kγ1. Other CCR3 ligands include CCL5, CCL24, CCL26, CCL8, CCL7, and CCL121.CCR3 is linked to several type-I allergy diseases, including allergic rhinitis. In addition to CCR3 expression in eosinophils, CCR3 is also expressed in basophils, microglia, astrocytes and neurons in both the developing and adult brain1,2.The expression of CCR3 increases following human immunodeficiency virus infection and in reactive microglia and astrocytes around the amyloid deposits in Alzheimer's disease2.
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基因ID
- 1232
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NCBI登录号
- NM_001164680
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UniProt
- P51677
抗原
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