CNR1 抗体 (Extracellular)
Quick Overview for CNR1 抗体 (Extracellular) (ABIN7043023)
抗原
See all CNR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 84-99, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Cannabinoid Receptor 1
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human - identical, mouse - 15,16 amino acid residues identical
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产品特性
- Anti-Cannabinoid Receptor 1 (extracellular) Antibody (ABIN7043023, ABIN7044155 and ABIN7044156) is a highly specific antibody directed against an epitope of the rat CB1 receptor. The antibody can be used in western blot, immunohistochemistry, and live cell imaging applications. It has been designed to recognize CB1 in human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: NKSLSSFKENEENIQC, corresponding to amino acid residues 84-99 of rat CB1 receptor
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亚型
- IgG
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anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibody
CNR1 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibodyVerified CNR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 73-122) antibodyCNR1 适用: 人, 大鼠, 猴, Cow, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (C-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠, 猴, 犬, Cow, 马, Bat, Pig IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) antibodyMicroarray verified CNR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB313026 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-110) antibodyCNR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (N-Term) antibodyCNR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (AA 1-117) antibodyCNR1 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 1 (CNR1) (Cytoplasmic Domain) antibodyCNR1 适用: 人, 大鼠, 小鼠, 猴, Hamster IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7235028)
Blocking Peptide: (ABIN7235028)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CNR1 (Cannabinoid Receptor 1 (CNR1))
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别名
- CNR1
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背景
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CB1, CB-R, CNR1, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor,Cannabinoids have been used in Eastern medicine for many years as pain relievers.1 Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 receptor) and cannabinoid receptor 2 (CB2 receptor).2 The cannabinoid receptors can be distinguished by their amino acid sequences, signaling mechanisms, and tissue distributions.2 Both receptors belong to the G-protein coupled receptor (GPCR) superfamily. CB1 was shown to modulate several Ca2+ and K+ ion channels.2,3CB1 is primarily expressed in the central nervous system. However, expression of CB1 is also detected in the peripheral terminals, in non-neuronal peripheral tissues such as uterus, testes, spleen, as well as in cells of the immune system.3,4CB1 is implicated in many cellular functions such as neurotransmitter release, pain relief, cancer, and obesity.5,6 Growth inhibition of tumor cells was demonstrated following mixed CB1/CB2 agonist treatment in both prostate and non-melanoma skin cancers.5,6 Through their interaction with CB1, cannabinoid compounds stimulate appetite for sweets and palatable foods in particular, making CB1 an attractive therapeutic target for the treatment of obesity and eating disorders.7
Alternative names: Cannabinoid Receptor 1, CB1, CB-R, CNR1, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor -
基因ID
- 25248
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NCBI登录号
- NM_001160226
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UniProt
- P20272
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途径
- Feeding Behaviour
抗原
-
