CALHM1 抗体 (Intracellular)
Quick Overview for CALHM1 抗体 (Intracellular) (ABIN7043013)
抗原
See all CALHM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 252-265, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Calcium Homeostasis Modulator 1
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - identical
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产品特性
- Anti-CALHM1 Antibody (ABIN7043013, ABIN7044044 and ABIN7044045) is a highly specific antibody directed against an epitope of the human calcium homeostasis modulator protein 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CALHM1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EAMNHDLELGHTHG, corresponding to amino acid residues 252-265 of human CALHM1
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亚型
- IgG
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anti-Calcium Homeostasis Modulator 1 (CALHM1) (N-Term) antibody
CALHM1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 202-346) antibodyCALHM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 202-346) antibodyCALHM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 295-344) antibodyCALHM1 适用: 人, 大鼠, 小鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 252-265), (Intracellular) antibody (Atto 594)CALHM1 适用: 人 IHC, IF, IC 宿主: 兔 Polyclonal Atto 594
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7235005)
Blocking Peptide: (ABIN7235005)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
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别名
- CALHM1
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背景
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Calcium homeostasis modulator 1, FAM26C,A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimer's disease (AD). Indeed, neuronal Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau1.Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism2,3. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum although it can be detected at the plasma membrane. A functional channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions1.In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD2.
Alternative names: CALHM1, Calcium homeostasis modulator 1, FAM26C -
基因ID
- 255022
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NCBI登录号
- NM_001001412
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UniProt
- Q8IU99
抗原
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