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- 抗原 See all CACNB1 抗体
- CACNB1 (Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1))
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抗原表位
- AA 456-471, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CACNB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to CACNB1 (CaVβ1) Subunit
- 特异性
- Intracellular, adjacent to the C-terminus
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Mouse - identical, human - 14,16
- 产品特性
- Anti-CACNB1 Antibody is directed against an epitope of rat CaVβ1. Anti-CACNB1 Antibody (ABIN7042984, ABIN7044049 and ABIN7044050) can be used in western blot and immunohistochemistry applications. It has been designed to recognize CaVβ1 from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DRATGEHASVHEYPGE, corresponding to amino acid residues 456-471 of rat CACNB1
- 亚型
- IgG
- Top Product
- Discover our top product CACNB1 Primary Antibody
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anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 500-598) antibody
CACNB1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1G6 unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (N-Term) antibodyCACNB1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 斑马鱼, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 429-598) antibodyCACNB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 21-70) antibodyCACNB1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 斑马鱼, 马, 猴, 非洲爪蟾, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) antibodyCACNB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 1-598) antibodyCACNB1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 201-250) antibodyCACNB1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 360-523) antibodyCACNB1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) (AA 143-192) antibodyCACNB1 适用: 人, 小鼠, 大鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) antibodyCACNB1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:800
- 说明
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Negative Control: (ABIN7234923)
Blocking Peptide: (ABIN7234923)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CACNB1 (Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1))
- 别名
- CACNB1 (CACNB1 产品)
- 背景
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CaVβ1, CAB1, CACNLB1, Voltage-dependent L-type calcium channel subunit beta-1,Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. Based on their electrophysiological and pharmacological properties, CaV channels have traditionally been classified into L, T, N, P, Q, and R types2. L-type Ca2+ channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+ flow across the membrane, and the subunits α2δ, γ, and β3. CaVβ subunits play critical roles in membrane trafficking of the channel complex and regulation of voltage-dependent gating. The CaVβ subunit binds to the endoplasmic reticulum (ER) retention signal in the I-II loop of the α1-subunit, which allows channels to traffic to the surface membrane4. Furthermore, CaVβ subunits not only allow for membrane trafficking of the channel complex, they also can play a role in determining the subcellular localization of channels on the surface membrane5. There are four distinct CaVβ subunits CaVβ1, CaVβ2, CaVβ3 and CaVβ46.Three splice variants exist for the β1 subunit: β1a, β1b and β1c. β1a is known to be expressed in skeletal muscle and brain, but not in smooth muscle or heart. β1a appears to be important for the functional expression of the α1 subunit in skeletal muscle7. β1b was identified by cloning in rat brain, heart and hippocampus, and differs from β1a by having a deletion of ~50 amino acids at residue 209, and having a 120-residue C-terminal elongation. β1c was cloned from human heart and hippocampus and has the same deletion as β1b, but lacks the C-terminal extension.
Alternative names: CACNB1, CaVbeta1, CAB1, CACNLB1, Voltage-dependent L-type calcium channel subunit beta-1 - 基因ID
- 50688
- NCBI登录号
- NM_000723
- UniProt
- P54283
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