CABP1 抗体 (Intracellular)
Quick Overview for CABP1 抗体 (Intracellular) (ABIN7042980)
抗原
See all CABP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 256-270, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Calcium-Binding Protein 1
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-CaBP1 Antibody is directed against an epitope of rat Calcium-binding protein 1. Anti-CaBP1 Antibody (ABIN7042980, ABIN7044206 and ABIN7044207) can be used in western blot analysis. It has been designed to recognize CaBP1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)REAMRKLLGHQVGHR, corresponding to amino acid residues 256-270 of rat CaBP1
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亚型
- IgG
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anti-Calcium Binding Protein 1 (CABP1) antibody
CABP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 1 (CABP1) (Internal Region) antibodyCABP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 1 (CABP1) (N-Term) antibodyVerified CABP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Calcium Binding Protein 1 (CABP1) (AA 311-343), (C-Term) antibodyCABP1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB15262 unconjugated
anti-Calcium Binding Protein 1 (CABP1) (C-Term) antibodyCABP1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 1 (CABP1) (N-Term) antibodyCABP1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:600
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说明
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Negative Control: (ABIN7234907)
Blocking Peptide: (ABIN7234907)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CABP1 (Calcium Binding Protein 1 (CABP1))
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别名
- CABP1
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背景
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Calcium-binding protein 1, Caldendrin, Calbrain,Neuronal Ca2+-binding proteins (CaBP1-5) are a subclass of the calmodulin (CaM) superfamily that regulates specific Ca2+ channel targets in the brain and retina. Multiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in sensory transduction and disease processes1.CaBP1-5 proteins have four EF hands that form pairs within the N lobe (EF1 and 2) and C lobe (EF3 and 4). The two lobes are structurally independent and connected by a flexible linker. Whereas all four EF hands bind Ca2+ in CaM, EF2 in CaBP1 does not bind Ca2+, and EF1 has reduced selectivity for Ca2+ over Mg2+. EF3 and EF4 in the C lobe of CaBP1 exhibit canonical Ca2+-induced conformational changes2. CaBP-target interactions induce functional changes distinct from those caused by CaM and may diversify neuronal responses to Ca2+ signals. CaBPs interact with and reshape the functional properties of certain voltage-gated Ca2+ channels (CaVs)3.CaBP1 is the best characterized family member and has been shown to regulate inositol 1,4,5-triphosphate receptors (IP3Rs), P/Q-type voltage-gated Ca2+ channels, L-type Ca2+ channels, and the transient receptor potential channel (TRPC5)4. CaBP1 regulates the currents of CaV1 and CaV2 channels in neurons, photoreceptors, and auditory hair cells. CaBP interactions with CaV1 channels may be required for hearing and vision, as mutations that disrupt these interactions cause blindness and deafness5.
Alternative names: CaBP1, Calcium-binding protein 1, Caldendrin, Calbrain -
基因ID
- 171051
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NCBI登录号
- NM_001033677
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UniProt
- O88751
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途径
- Synaptic Membrane, Negative Regulation of Transporter Activity
抗原
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