CALCRL 抗体 (Extracellular)
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- 抗原 See all CALCRL 抗体
- CALCRL (Calcitonin Receptor-Like (CALCRL))
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抗原表位
- AA 127-140, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CALCRL antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Live Cell Imaging (LCI), Immunofluorescence (Cultured Cells) (IF (cc))
- 原理
- A Rabbit Polyclonal Antibody to Calcitonin Receptor-Like Receptor
- 特异性
- Extracellular, N-terminus.
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,rat - 12,14 amino acid residues identical
- 产品特性
- Anti-CRLR/CALCRL (extracellular) Antibody (ABIN7042979, ABIN7044198 and ABIN7044199)) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and indirect live cell flow cytometry. It has been designed to recognize CRLR from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EQMQKVRGFR(S)GKKS, corresponding to amino acid residues 522 - 536 of mouse OCTN1
- 亚型
- IgG
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anti-Calcitonin Receptor-Like (CALCRL) antibody
CALCRL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (Cytoplasmic Domain) antibodyCALCRL 适用: 人, 大鼠, Cow, 犬, 马, 兔, 山羊, 猴, Hamster, Pig, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 23-132) antibodyCALCRL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 340-367) antibodyCALCRL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22070 unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (C-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 108-157) antibodyCALCRL 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 392-461) antibodyCALCRL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (N-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-CR060
Blocking Peptide: BLP-CR060
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CALCRL (Calcitonin Receptor-Like (CALCRL))
- 别名
- CALCRL (CALCRL 产品)
- 背景
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Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR,Calcitonin Receptor-Like Receptor 1 (CRLR or CGRPR) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism1.When engaged with its substrate, calcitonin gene related peptide (CGRP), CGRPR activates cAMP-dependent pkA and PI3 kinase, which eventually leads to complex inhibitory as well as facilitator actions on Neuronal Nicotinic Acetylcholine Receptor1.CGRP receptor is a heterodimer composed of two proteins: a 7-transmembrane domain type 2 G-protein coupled receptor called calcitonin-receptor-like receptor (CRLR), and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. RAMP1 serves as a transporter for CRLR to the cell surface and its absence leads to failure of binding with CRLR2.CGRP and CGRPR are ubiquitously expressed and their interaction is related to various diseases and health states such as migraines3 and Alzheimer's disease1.
Alternative names: Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR - 基因ID
- 10203
- NCBI登录号
- NM_005795
- UniProt
- Q16602
- 途径
- cAMP Metabolic Process
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