CALCRL 抗体 (Extracellular, N-Term) (FITC)
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Quick Overview for CALCRL 抗体 (Extracellular, N-Term) (FITC) (ABIN7237607)
抗原
See all CALCRL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 127-140, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to CRLR/CALCRL (extracellular) conjugated to the fluorescent dye FITC
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 12 out of 14 amino acid residues identical
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产品特性
- Extracellular, N-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CNVNTHEKVKTALN, corresponding to amino acid residues 127 - 140 of human Calcitonin Receptor-Like Receptor
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亚型
- IgG
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anti-Calcitonin Receptor-Like (CALCRL) (AA 127-140), (Extracellular), (N-Term) antibody
CALCRL 适用: 人 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (Cytoplasmic Domain) antibodyCALCRL 适用: 人, 大鼠, Cow, 犬, 马, 兔, 山羊, 猴, Hamster, Pig, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 340-367) antibodyCALCRL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22070 unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 23-132) antibodyCALCRL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (N-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (C-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 392-461) antibodyCALCRL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 108-157) antibodyCALCRL 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7234904)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CALCRL (Calcitonin Receptor-Like (CALCRL))
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别名
- CALCRL
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背景
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Synonyms: Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR
Description: Calcitonin Receptor-Like Receptor 1 (CRLR or CGRPR) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism1.When engaged with its substrate, calcitonin gene related peptide (CGRP), CGRPR activates cAMP-dependent pkA and PI3 kinase, which eventually leads to complex inhibitory as well as facilitator actions on Neuronal Nicotinic Acetylcholine Receptor1.CGRP receptor is a heterodimer composed of two proteins: a 7-transmembrane domain type 2 G-protein coupled receptor called calcitonin-receptor-like receptor (CRLR), and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. RAMP1 serves as a transporter for CRLR to the cell surface and its absence leads to failure of binding with CRLR2.CGRP and CGRPR are ubiquitously expressed and their interaction is related to various diseases and health states such as migraines3 and Alzheimer's disease1.
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基因ID
- 10203
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NCBI登录号
- NM_032513
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UniProt
- Q16602
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途径
- cAMP Metabolic Process
抗原
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