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N-Cadherin 抗体 (Intracellular)

The 兔多克隆 anti-N-Cadherin antibody is suitable to detect N-Cadherin in samples from 小鼠. It has been validated for WB 和 IHC.

Western blot analysis of mouse brain (lanes 1 and 5), mouse heart (lanes 2 and 6), rat heart (lanes 3 and 7) and human brain neuroblastoma (SH-SY5Y) (lanes 4 and 8) cell lysates: - 1-4. (N-Cadherin 抗体 (Intracellular))

Expression of N-Cadherin in mouse cortex - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-N-Cadherin Antibody (ABIN7042976, ABIN7044708 and ABIN7044709), (1:200), followed by goat anti-rabbit-AlexaFluor-488. (N-Cadherin 抗体 (Intracellular))

IHC

2 images

产品编号 ABIN7042976

发货至: 中国

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Quick Overview for N-Cadherin 抗体 (Intracellular) (ABIN7042976)

抗原

See all N-Cadherin (CDH2) 抗体

N-Cadherin (CDH2) (Cadherin 2 (CDH2))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This N-Cadherin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product CDH2 Primary Antibody

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AA 794-807, Intracellular

原理

A Rabbit Polyclonal Antibody to N-Cadherin

交叉反应

人, 小鼠, 大鼠

预测反应

Rat,human - identical

产品特性

Anti-N-Cadherin Antibody (ABIN7042976, ABIN7044708 and ABIN7044709) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize CDH2 from rat, mouse, and human samples.

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)DTVEPDAIKPVGIR, corresponding to amino acid residues 794-807 of mouse CDH2

亚型

IgG
anti-Cadherin 2 (CDH2) (AA 701-800) antibody
CDH2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) antibody
CDH2 适用: 人, 小鼠, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2G7 unconjugated

anti-Cadherin 2 (CDH2) (AA 750-850) antibody
CDH2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) antibody
CDH2 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 5D5 unconjugated

anti-Cadherin 2 (CDH2) (AA 45-238) antibody
CDH2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (AA 160-724) antibody
CDH2 适用: 人, 小鼠 WB, IP, FACS, ICC 宿主: 兔 Monoclonal BLR097G unconjugated Recombinant Antibody

anti-Cadherin 2 (CDH2) (AA 690-770) antibody
CDH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (AA 295-414) antibody
CDH2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (AA 685-784) antibody
CDH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (Extracellular Domain) antibody
CDH2 适用: 人, 小鼠 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 8C11 unconjugated

应用备注

WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7234896)
Blocking Peptide: (ABIN7234896)

限制

仅限研究用
状态

Lyophilized

溶解方式

25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

浓度

0.8 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

N-Cadherin (CDH2) (Cadherin 2 (CDH2))

别名

CDH2

背景

Synonyms: Cadherin 2, Neural cadherin, CDH2, NCAD, CDHN, CD325, Calcium-dependent adhesion protein neuronal
Description: Cadherins are transmembrane proteins responsible for cell adhesion. Cell adhesion is a crucial feature for the sustainability and maintenance of normal tissue function and three dimensional structure. Cadherins share an extracellular domain consisting of multiple repeats of cadherin-specific motif and are calcium dependent homotypic cell-to-cell adhesion molecules. They are localized mostly in specialized sites called adherence junctions1.N-cadherin consists of an amino-terminal external domain with five tandem repeats, a single transmembrane segment, and a cytoplasmic carboxy-terminal domain of approximately 150 amino acids. The intracellular domain of N-cadherin interacts with a group of proteins called catenins that are essential for cadherin-mediated cell adhesion. It is suggested that N-cadherin proteins align in a form of "zipper" when involved in cell adhesion. Cadherins on one cell surface form a series of rigid dimers that attach to equivalent dimers on the opposing cells and lateral motion of these complexes allows the cell junction site to "zip up"1.N-cadherin plays a role in tumor metastasis. Unlike E-cadherin that causes tumor metastasis when insufficiently, N-cadherin is involved in tumor metastasis when upregulated. N-cadherin stimulates migration, invasion and metastasis of squamous cell breast cancer and its effects are increased by FGF-2 suggesting that N-cadherin and FGFR-1 synergize and promote aggressive tumor behavior. This synergy also promotes neuronal growth1. Interestingly, low levels of N-cadherin are associated with a higher invasive capacity of astrocytic glioma by increasing tumor (and normal) cell migration speed and creating a less organized pattern of migration3.

基因ID

12558

NCBI登录号

NM_001792

UniProt

P15116

途径

Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane