BDKRB2 抗体 (Intracellular)
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- 抗原 See all BDKRB2 抗体
- BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
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抗原表位
- AA 336-349, Intracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BDKRB2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to B2 Bradykinin Receptor
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- mouse - 11,Rat - 12,13 amino acid residues identical
- 产品特性
- Anti-B2 Bradykinin Receptor (BDKRB2) Antibody (ABIN7042968, ABIN7043942 and ABIN7043943)) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize B2R from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: GKRFRKKSWEVYQG(C), corresponding to amino acid residues 336-349 of human B2R
- 亚型
- IgG
- Top Product
- Discover our top product BDKRB2 Primary Antibody
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anti-Bradykinin Receptor B2 (BDKRB2) (AA 51-150) antibody
BDKRB2 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 302-391) antibodyBDKRB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 336-391) antibodyBDKRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:1000
- 说明
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Cited Application: IHC
Negative Control: BLP-BR012
Blocking Peptide: BLP-BR012
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
- 别名
- BDKRB2 (BDKRB2 产品)
- 背景
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B2R, BKR2, B2BKR, BKRB2, Kinin B2, BRADYB2,Kinins are small peptides produced rapidly following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) seem to initiate a similar cascade of events leading to neural tissue damage, as well as long lasting disturbances affecting blood-brain barrier function.1Kinins, such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK, exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). BKRB2 is activated by BK and Lys-BK while desArg9-BK and Lys-desArg9-BK activate BKRB1.2 Activation of BKRB2 liberates mediators of vascular tone, fibrinolysis, and pain. BKRB2, which mediates most of the physiological effects of kinins, as well as BKRB1, represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxy terminus.BKRB2 is constitutively and widely expressed throughout the CNS and peripheral nervous system and on various cell types including endothelial cells, nerve fibers, leukocytes, and mast cells.3-5
Alternative names: B2 Bradykinin Receptor (BDKRB2), B2R, BKR2, B2BKR, BKRB2, Kinin B2, BRADYB2 - 基因ID
- 624
- NCBI登录号
- NM_000623
- UniProt
- P30411
- 途径
- ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling
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