BDKRB2 抗体 (C-Term, Intracellular)
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Quick Overview for BDKRB2 抗体 (C-Term, Intracellular) (ABIN7886089)
抗原
See all BDKRB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 336-349, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to B2 Bradykinin Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- mouse - 11,Rat - 12,13 amino acid residues identical
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产品特性
- Anti-B2 Bradykinin Receptor (BDKRB2) Antibody (ABIN7042968, ABIN7043942 and ABIN7043943) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize B2R from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- GKRFRKKSWEVYQG(C), corresponding to amino acid residues 336-349 of human B2R
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亚型
- IgG
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anti-Bradykinin Receptor B2 (BDKRB2) (AA 51-150) antibody
BDKRB2 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (C-Term) antibodyBDKRB2 适用: 人, 小鼠, 大鼠 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 302-391) antibodyBDKRB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 336-391) antibodyBDKRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) antibodyBDKRB2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3710 unconjugated Recombinant Antibody
anti-Bradykinin Receptor B2 (BDKRB2) antibodyBDKRB2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4725 unconjugated Recombinant Antibody
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:1000
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7234872)
Blocking Peptide: (ABIN7234872)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
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别名
- BDKRB2
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背景
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Synonyms: B2R, BKR2, B2BKR, BKRB2, Kinin B2, BRADYB2
Description: Kinins are small peptides produced rapidly following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) seem to initiate a similar cascade of events leading to neural tissue damage, as well as long lasting disturbances affecting blood-brain barrier function.1Kinins, such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK, exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). BKRB2 is activated by BK and Lys-BK while desArg9-BK and Lys-desArg9-BK activate BKRB1.2 Activation of BKRB2 liberates mediators of vascular tone, fibrinolysis, and pain. BKRB2, which mediates most of the physiological effects of kinins, as well as BKRB1, represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxy terminus.BKRB2 is constitutively and widely expressed throughout the CNS and peripheral nervous system and on various cell types including endothelial cells, nerve fibers, leukocytes, and mast cells.3-5
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基因ID
- 624
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NCBI登录号
- NM_000623
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UniProt
- P30411
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途径
- ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling
抗原
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