BDKRB1 抗体 (3rd Intracellular Loop, C250S)
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Quick Overview for BDKRB1 抗体 (3rd Intracellular Loop, C250S) (ABIN7886088)
抗原
See all BDKRB1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Intracellular Loop, AA 243-257, C250S
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原理
- A Rabbit Polyclonal Antibody to B1 Bradykinin Receptor
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Might not recognize the human epitope.
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预测反应
- Mouse - 13,15 amino acid residues identical
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产品特性
- Anti-B1 Bradykinin Receptor (BDKRB1) Antibody (ABIN7042967, ABIN7043940 and ABIN7043941) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize B1R from rat and mouse samples. The antibody may not recognize the receptor from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KEAS RTR*SG GPKGS K, corresponding to amino acid residues 243-257 of rat B1R with replacement of cysteine 250 (C250) with serine (*S)
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亚型
- IgG
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anti-Bradykinin Receptor B1 (BDKRB1) (AA 161-260) antibody
BDKRB1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Cytoplasmic Domain) antibodyBDKRB1 适用: 人 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Extracellular Domain) antibodyBDKRB1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (C-Term) antibodyBDKRB1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 202-214), (Extracellular), (Loop 2) antibodyBDKRB1 适用: 小鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 1-353) antibodyBDKRB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (Internal Region) antibodyVerified BDKRB1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Bradykinin Receptor B1 (BDKRB1) (AA 230-279) antibodyBDKRB1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7234868)
Blocking Peptide: (ABIN7234868)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- BDKRB1 (Bradykinin Receptor B1 (BDKRB1))
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别名
- BDKRB1
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背景
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Synonyms: B1R, BKR1, B1BKR, BKRB1, Kinin B1, BRADYB1
Description: Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function.1Kinins such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). The desArg9-BK and Lys-desArg9-BK peptides activate BKRB1 while BK and Lys-BK operate by activating BKRB2.2 Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Expression of BKRB1is inducible upon various types of tissue injury and by inflammatory mediators such as bacterial lipopolysaccharide (LPS) and cytokines. BKRB1 was long considered not to be expressed in healthy tissues. However, recent work has demonstrated a low level of expression of BKRB1 in the CNS of rodent and primates. In contrast, BKRB2 is constitutively expressed on various cell types.3 BKRB1 represents a potential therapeutic target for treatment of inflammatory disorders and cardiovascular diseases.
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基因ID
- 81509
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NCBI登录号
- NM_000710
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UniProt
- P97583
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途径
- ACE Inhibitor Pathway
抗原
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