ADRA1D 抗体 (C240S, Extracellular)
Quick Overview for ADRA1D 抗体 (C240S, Extracellular) (ABIN7042896)
抗原
See all ADRA1D 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 231-245, C240S, Extracellular
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原理
- A Rabbit Polyclonal Antibody to α1D-Adrenergic Receptor
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特异性
- 3rd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human,mouse - 14,15 amino acid residues identical
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产品特性
- Anti-alpha1D-Adrenergic Receptor (extracellular) Antibody is directed against an extracellular epitope of the rat α1D-adrenergic receptor. Anti-α1D-Adrenergic Receptor (extracellular) Antibody (ABIN7042896, ABIN7043916 and ABIN7043917) can be used in western blot, indirect flow cytometry and immunohistochemical applications. It has been designed to recognize α1D-adrenoceptor from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EPVPPDERF*SGITEE, corresponding to amino acid residues 231-245 of rat alpha1D-adrenoceptor with replacement of cysteine 240 (C240) with serine (*S)
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亚型
- IgG
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anti-Adrenergic Receptor, alpha 1d (ADRA1D) (AA 1-30), (N-Term) antibody
ADRA1D 适用: 人, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB46798 unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (AA 286-335) antibodyADRA1D 适用: 人, 大鼠, 小鼠, 犬, 马, Cow, 豚鼠, 兔, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (C-Term) antibodyADRA1D 适用: 人, 大鼠, 小鼠 IHC, WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (N-Term) antibodyADRA1D 适用: 人, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (Extracellular Domain) antibodyADRA1D 适用: 人, 犬, 马, 豚鼠, 猴, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (Cytoplasmic Domain) antibodyADRA1D 适用: 人, 犬, 马, Cow, 兔, 猴, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) antibodyADRA1D 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (C-Term) antibodyADRA1D 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (C-Term) antibodyADRA1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic Receptor, alpha 1d (ADRA1D) (AA 451-500) antibodyADRA1D 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7234657)
Blocking Peptide: (ABIN7234657)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- ADRA1D (Adrenergic Receptor, alpha 1d (ADRA1D))
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别名
- ADRA1D
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背景
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Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, ADRA1D,Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. The adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. α1-Adrenergic receptors play an important role in the physiological response to epinephrine and norepinephrine, particularly in the cardiovascular system. All three cloned α1 receptors (α1A, α1B, and α1D) couple to Gq/11. While their cellular distribution is clear, their functional role is less so due to a lack of specific agonists/antagonists3. As these receptors lack specific agonists/antagonists, knock-out (KO) studies in mice have shed significant light on their cellular role. Individual α1-adrenoceptor KO mice do not display physical abnormalities in general. Similar KO studies indicate that all α1 subtypes seem to be involved in the regulation of blood pressure3. Also, studies indicate that α1D-adrenoceptor seems to play an important role in aortic contraction4, renal function, nociception, basal locomotor activity3 as well as bladder contraction5.
Alternative names: alpha1D-Adrenergic Receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, ADRA1D -
基因ID
- 29413
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NCBI登录号
- NM_000678
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UniProt
- P23944
抗原
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