Adenosine A3 Receptor 抗体 (3rd Intracellular Loop)
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Quick Overview for Adenosine A3 Receptor 抗体 (3rd Intracellular Loop) (ABIN7042891)
抗原
See all Adenosine A3 Receptor (ADORA3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Intracellular Loop, AA 216-230
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原理
- A Rabbit Polyclonal Antibody to Adenosine A3 Receptor
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交叉反应
- 人, 大鼠
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预测反应
- Rat,mouse - 14,16 amino acid residues identical
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产品特性
- Anti-Adenosine A3 Receptor Antibody is directed against an intracellular epitope of the human adenosine A3 receptor (A3AR). Anti-Adenosine A3 Receptor Antibody (ABIN7042891, ABIN7043892 and ABIN7043893) can be used in western blot analysis, as well as immunocytochemical and immunohistocemical applications, and has been designed to recognize A3AR from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KETGAFYGREFKTAK, corresponding to amino acid residues 216-230 of human A3AR
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亚型
- IgG
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anti-Adenosine A3 Receptor (ADORA3) (AA 85-180) antibody
ADORA3 适用: 人, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) antibodyADORA3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 121-225) antibodyADORA3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人, Pig, Cow, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 149-161), (Extracellular), (Loop 2) antibodyADORA3 适用: 小鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 202-232) antibodyADORA3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53326 unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (Cytoplasmic Domain) antibodyADORA3 适用: 人, Pig, 犬, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 247-296) antibodyADORA3 适用: 人, Pig, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:100
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234639)
Blocking Peptide: (ABIN7234639)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Adenosine A3 Receptor (ADORA3)
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别名
- ADORA3
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背景
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Synonyms: ADORA3, A3AR, Adenosine A3R
Description: Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4 All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important in binding G proteins.1-3Expression of A3AR has been reported in the brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases.
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基因ID
- 140
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UniProt
- P0DMS8
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途径
- Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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